Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut.
Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut.
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DOI：
10.4161/gmic.25487
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发表时间：
2013-07
期刊：
影响因子：
12.2
通讯作者：
Quigley EM
中科院分区：
文献类型：
--
作者：
Groeger D;O'Mahony L;Murphy EF;Bourke JF;Dinan TG;Kiely B;Shanahan F;Quigley EM
某些治疗性微生物，包括双歧杆菌（B. 35624通过模拟胃肠道-免疫相互作用发挥有益的免疫调节作用;然而，这些作用在患有非胃肠道炎性病症的患者中的价值仍不清楚。在这项研究中，我们评估了口服B的影响。在三个单独的随机、双盲、安慰剂对照干预中，对溃疡性结肠炎（UC）（n = 22）、慢性疲劳综合征（CFS）（n = 48）和银屑病（n = 26）患者的炎症生物标志物和血浆细胞因子水平进行为期6 - 8周的研究。此外，B.在健康受试者（n = 22）中评估了抗肿瘤药物35624对免疫学生物标志物的影响。基线时，与健康志愿者相比，胃肠道（UC）和非胃肠道（CFS和银屑病）患者的C反应蛋白（CRP）、促炎细胞因子肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）血浆水平均显著升高。B。与安慰剂相比，在所有三种炎症性疾病中，喂食35624导致血浆CRP水平降低。有趣的是，CFS和银屑病患者的血浆TNF-α降低，而UC和CFS患者的IL-6降低。此外，在健康受试者中，B组中LPS刺激的外周血单核细胞（PBMC）分泌TNF-α和IL-6显著减少。喂食8周后，与安慰剂组相比，给药组中的E35624。这些结果证明了这种微生物在胃肠道和非胃肠道条件下减少全身促炎生物标志物的能力。总之，这些数据表明，人体内微生物群的免疫调节作用不仅限于粘膜免疫系统，还扩展到全身免疫系统。
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert beneficial immunoregulatory effects by mimicking commensal-immune interactions; however, the value of these effects in patients with non-gastrointestinal inflammatory conditions remains unclear. In this study, we assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis (UC) (n = 22), chronic fatigue syndrome (CFS) (n = 48) and psoriasis (n = 26) in three separate randomized, double-blind, placebo-controlled interventions. Additionally, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects (n = 22) was assessed. At baseline, both gastrointestinal (UC) and non-gastrointestinal (CFS and psoriasis) patients had significantly increased plasma levels of C-reactive protein (CRP) and the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) compared with healthy volunteers. B. infantis 35624 feeding resulted in reduced plasma CRP levels in all three inflammatory disorders compared with placebo. Interestingly, plasma TNF-α was reduced in CFS and psoriasis while IL-6 was reduced in UC and CFS. Furthermore, in healthy subjects, LPS-stimulated TNF-α and IL-6 secretion by peripheral blood mononuclear cells (PBMCs) was significantly reduced in the B. infantis 35624-treated groups compared with placebo following eight weeks of feeding. These results demonstrate the ability of this microbe to reduce systemic pro-inflammatory biomarkers in both gastrointestinal and non-gastrointestinal conditions. In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
--
作者：
Glintborg, Bente;Ostergaard, Mikkel;Hetland, Merete Lund
通讯作者：
Hetland, Merete Lund
影响因子：
3.6
作者：
Andreasen, Anne Sofie;Larsen, Nadja;Pedersen, Bente Klarlund
通讯作者：
Pedersen, Bente Klarlund
影响因子：
24.5
作者：
Konieczna, Patrycja;Groeger, David;O'Mahony, Liam
通讯作者：
O'Mahony, Liam
DOI：
10.1177/039463201002300423
发表时间：
2010-10-01
影响因子：
3.5
作者：
Gisondi, P.;Malerba, M.;Girolomoni, G.
通讯作者：
Girolomoni, G.