Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population.
Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population.
复制标题
FAM167A-BLK基因单核苷酸多态性与中国汉族人群多发性肌炎/皮肌炎相关
DOI：
10.1007/s12026-015-8646-0
复制
发表时间：
2015-06
影响因子：
4.4
通讯作者：
Li, Yongzhe
中科院分区：
文献类型：
--
作者：
Chen, Si;Wu, Wei;Li, Jing;Wang, Qian;Li, Yuan;Wu, Ziyan;Zheng, Wenjie;Wu, Qingjun;Wu, Chanyuan;Zhang, Fengchun;Li, Yongzhe
Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases influenced by genetic background and environmental factors. Recently, FAM167A-BLK gene has been identified as a potential genetic susceptibility locus for dermatomyositis (DM) in patients of European and Japanese populations. Our aim here was to investigate the association between FAM167A-BLK polymorphisms and IIMs risk in Chinese Han. The FAM167A-BLK single nucleotide polymorphisms (SNPs) rs2736340, rs7812879, rs13277113, rs2618479, rs2254546 and rs2248932 were analyzed in polymyositis (PM) patients (n= 310), DM patients (n= 535) and 968 ethnically matched healthy controls, with the Sequenom MassArray system. Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (Pc= 6.48 × 10−3;Pc= 0.013, respectively), rs7812879 (Pc= 0.017;Pc= 0.034, respectively) and rs13277113 (Pc= 0.011;Pc= 0.047, respectively). These three SNPs were significantly associated with interstitial lung disease (ILD) in overall PM/DM patients (all,Pc< 0.05). The frequency of the five haplotypes of the five SNPs (rs2736340, rs7812879, rs13277113, rs2618479 and rs2254546) was also significantly different between overall PM/DM, PM or DM patients and healthy controls. This was the first study to demonstrate that the FAM167A-BLK polymorphisms were associated with Chinese PM/DM patients or these patients with ILD, indicating that PM/DM might share common gene with other autoimmune diseases.
登录
查看更多内容
影响因子：
5.5
作者：
Chinoy, H.;Salway, F.;Cooper, R. G.
通讯作者：
Cooper, R. G.
影响因子：
27.4
作者：
Kikuchi, Y;Koarada, S;Nagasawa, K
通讯作者：
Nagasawa, K
影响因子：
5
作者：
Nordmark, G.;Kristjansdottir, G.;Syvanen, A-C
通讯作者：
Syvanen, A-C
影响因子：
4.9
作者：
Chinoy H;Lamb JA;Ollier WE;Cooper RG
通讯作者：
Cooper RG
影响因子：
2.3
作者：
Mastaglia, FL;Phillips, BA
通讯作者：
Phillips, BA