Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.
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卟啉和邻苯烷在光动力疗法,成像和疗法学中的独特诊断和治疗作用。

DOI:
10.7150/thno.4571
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发表时间:
2012
期刊:
影响因子:
12.4
通讯作者:
Boyle RW
Boyle RW
中科院分区:
医学1区
文献类型:
--
作者:
Josefsen LB;Boyle RW

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卟啉分子在疾病治疗中具有独特的治疗诊断作用;它们已被用于成像、检测和治疗不同形式的患病组织,包括年龄相关性黄斑变性和许多不同的癌症类型。目前的重点是肿瘤组织的临床成像;光敏剂的靶向递送和光敏剂在多模式生物医学治疗诊断纳米平台中的潜力。卟啉分子在成像和光动力学,沿着研究到提高其在病变组织中的选择性摄取和其在治疗诊断应用中的作用是突出在这次审查。
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.
通过阳离子中二取代的卟啉对革兰氏阴性和革兰氏阳性细菌的光活化的电荷效应。
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