Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter
Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter
复制标题
利用绝缘体上硅 (SOI) 微剂量计进行多离子治疗的微剂量研究
DOI：
10.1088/1361-6560/ac8968
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Inaniwa Taku
中科院分区：
文献类型：
--
作者：
Sakata Dousatsu;Lee Sung Hyun;Tran Linh T;Pan Vladimir;Nakaji Taku;Mizuno Hideyuki;Kok Angela;Povoli Marco;Rosenfeld Anatoly;Inaniwa Taku
质子或碳离子放射治疗是目前临床上最先进的癌症治疗方法之一。为了进一步改善局部肿瘤控制，已经研究了使用多个离子种类的离子放射疗法。由于多离子治疗在肿瘤中递送的剂量分布的复杂性，必须建立用于计划的治疗功效的验证策略，其可以潜在地用于多离子治疗计划的质量保证（QA）协议。在以前的工作中，我们证明了使用绝缘体上硅（SOI）微剂量计的微剂量测定方法对于在氦，碳，氧和氖离子束的独立场中验证MIA PaCa-2细胞的细胞存活分数（SF）是实用的。并且我们展示了基于微剂量测定的方法作为试点研究，以在多离子治疗中建立QA协议，预测细胞SF沿着扩散-用He+ O和C+ Ne离子组合辐照获得了外布拉格峰。在整个研究中，利用SOI微剂量计系统MicroPlus测量了单个离子场的线性能量，然后利用HIMAC的笔形束扫描系统导出了组合离子场的线性能量。所呈现的结果表明SOI微剂量计系统MicroPlus作为多离子放射治疗中的QA系统的潜在益处。
ObjectiveIon radiotherapy with protons or carbon ions is one of the most advanced clinical methods for cancer treatment. To further improve the local tumor control, ion radiotherapy using multiple ion species has been investigated. Due to complexity of dose distributions delivered by multi-ion therapy in a tumor, a validation strategy for the planned treatment efficacy must be established that can be potentially used in the quality assurance (QA) protocol for the multi-ion treatment plans. In previous work, we demonstrated that the microdosimetric approach using the silicon on insulator (SOI) microdosimeter is practical for validating cell surviving fraction (SF) of MIA PaCa-2 cells in the independent fields of helium, carbon, oxygen, and neon ion beams.ApproachThis paper extends the previous study, and we demonstrate a microdosimetry based approach as a pilot study to build the QA protocol in the multi-ion therapy predicting the cell SF along the spread-out Bragg peak obtained by combined irradiations of He+ O and C+ Ne ions. Across the study, the SOI microdosimeter system MicroPlus was used for measurement of the lineal energy in individual ion fields followed by deriving the lineal energy of combined ion fields delivered by a pencil beam scanning system at HIMAC.Main resultsThe predicted cell SF based on derived lineal energy and dose in the combined fields was in good agreement with the planned cell SF by our in-house treatment planning system.SignificanceThe presented results indicated the potential benefit of the SOI microdosimeter system MicroPlus as the QA system in the multi-ion radiotherapy.
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大分割多离子治疗的随机微剂量动力学模型
DOI：
--
发表时间：
2020
期刊：
影响因子：
--
作者：
小久江良太;前田正幸;T. Inaniwa
通讯作者：
T. Inaniwa
影响因子：
2.6
作者：
M. R. Raju;E. Bain;S. Carpenter;R. A. Cox;J. Robertson
通讯作者：
J. Robertson
影响因子：
3.4
作者：
Kase, Yuki;Kanai, Tatsuaki;Shinoda, Hiroshi
通讯作者：
Shinoda, Hiroshi
影响因子：
3.8
作者：
Kraemer, Michael;Scifoni, Emanuele;Durante, Marco
通讯作者：
Durante, Marco
影响因子：
3.5
作者：
Sokol, O.;Kraemer, M.;Scifoni, E.
通讯作者：
Scifoni, E.