Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19.
Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19.
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DOI：
10.1186/s12974-021-02323-8
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发表时间：
2021-11-27
影响因子：
9.3
通讯作者：
Choi HA
中科院分区：
文献类型：
--
作者：
Savarraj J;Park ES;Colpo GD;Hinds SN;Morales D;Ahnstedt H;Paz AS;Assing A;Liu F;Juneja S;Kim E;Cho SM;Gusdon AM;Dash P;McCullough LD;Choi HA
虽然新冠肺炎是一种呼吸道疾病，但包括大脑在内的所有器官都可能受到影响。到目前为止，对脑损伤标记物(BIM)和内皮损伤标记物(EIM)的具体研究还很有限。此外，新冠肺炎后男性在疾病严重程度和死亡率方面的偏见在全球范围内都很明显。对新冠肺炎的免疫反应中的性别差异可能调节了这种差异。我们调查了新冠肺炎治疗后和不同性别患者的骨髓间充盈指数、内膜间充盈指数和炎性细胞因子/趋化因子水平。对57名在 <； 住院48小时的新冠肺炎受试者和20名匹配的对照组的血浆样本进行了6种BIM水平的询问，包括胶质纤维酸性蛋白、S100B、Syndecan-1、UCHLI、MAP2和NSE，以及2种EIM，包括sICAM 1和sVCAM1。此外，还对几种细胞因子/趋化因子进行了多重分析。统计和生物信息学方法被用来衡量(A)新冠肺炎与对照组以及(B)男性与女性之间标记物特征的差异。3个BIM：MAP2、NSE和S100B，2个EIM：sICAM 1和sVCAM1和7个CC：Gro IL 10、sCD40L、IP10、IL 1ra、MCP1和肿瘤坏死因子α在新冠肺炎队列中显著高于对照组(p <； 0.05)。生物信息学分析显示，新冠肺炎队列中的BIM/CC/EIM之间存在较强的正相关关系。跨性别分析显示，男性的多项BIM和CC，包括NSE、IL10、IL15和IL8显著高于女性(p <； 0.05)。与女性相比，男性也表达了更强大的BIM/EIM/CC关联概况。新冠肺炎入院时，BIM、CCS和EIMS的急性升高以及它们之间的强烈相关性提示脑损伤和内皮损伤。男性较高的BIM和炎症标志物还表明，男性比女性更容易患上这种风险。网上版载有补充材料，可在10.1186/s12974-021-02323-8查阅。
Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial injury markers (EIM) have been limited. Additionally, a male bias in disease severity and mortality after COVID-19 is evident globally. Sex differences in the immune response to COVID-19 may mediate this disparity. We investigated BIM, EIM and inflammatory cytokine/chemokine (CC) levels after COVID-19 and in across sexes. Plasma samples from 57 subjects at < 48 h of COVID-19 hospitalization, and 20 matched controls were interrogated for the levels of six BIMs—including GFAP, S100B, Syndecan-1, UCHLI, MAP2 and NSE, two EIMs—including sICAM1 and sVCAM1. Additionally, several cytokines/chemokines were analyzed by multiplex. Statistical and bioinformatics methods were used to measure differences in the marker profiles across (a) COVID-19 vs. controls and (b) men vs. women. Three BIMs: MAP2, NSE and S100B, two EIMs: sICAM1 and sVCAM1 and seven CCs: GRO IL10, sCD40L, IP10, IL1Ra, MCP1 and TNFα were significantly (p < 0.05) elevated in the COVID-19 cohort compared to controls. Bioinformatics analysis reveal a stronger positive association between BIM/CC/EIMs in the COVID-19 cohort. Analysis across sex revealed that several BIMs and CCs including NSE, IL10, IL15 and IL8 were significantly (p < 0.05) higher in men compared to women. Men also expressed a more robust BIM/ EIM/CC association profile compared to women. The acute elevation of BIMs, CCs, and EIMs and the robust associations among them at COVID-19 hospitalization are suggestive of brain and endothelial injury. Higher BIM and inflammatory markers in men additionally suggest that men are more susceptible to the risk compared to women. The online version contains supplementary material available at 10.1186/s12974-021-02323-8.
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IP-10 和 MCP-1 作为与 COVID-19 疾病严重程度相关的生物标志物。
DOI：
10.1186/s10020-020-00230-x
发表时间：
2020-10-29
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Chen Y;Wang J;Liu C;Su L;Zhang D;Fan J;Yang Y;Xiao M;Xie J;Xu Y;Li Y;Zhang S
通讯作者：
Zhang S
影响因子：
3.5
作者：
Helwig, Kirsten;Seeger, Florian;Foerch, Christian
通讯作者：
Foerch, Christian
影响因子：
6.5
作者：
Clark, Paul R.;Manes, Thomas D.;Kluger, Martin S.
通讯作者：
Kluger, Martin S.
影响因子：
11.8
作者：
Lau KK;Yu WC;Chu CM;Lau ST;Sheng B;Yuen KY
通讯作者：
Yuen KY
多器官感染和SAR的发病机理。
影响因子：
15.3
作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
通讯作者：
Leong, Anthony S-Y