Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
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关节炎微环境驱动的纳米马达用于治疗活动性类风湿关节炎
DOI：
10.1002/advs.202204881
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发表时间：
2023-03
期刊：
影响因子：
15.1
通讯作者：
Tu, Yingfeng
中科院分区：
文献类型：
--
作者：
Xu, Cong;Jiang, Yuejun;Wang, Hong;Zhang, Yuxin;Ye, Yicheng;Qin, Hanfeng;Gao, Junbin;Dan, Qing;Du, Lingli;Liu, Lu;Peng, Fei;Li, Yingjia;Tu, Yingfeng
Increasing O2 demand and excessive ROS production are the main features of arthritic microenvironment in rheumatoid arthritis (RA) joints and further play pivotal roles in inflammation exacerbation. In this work, a system of in situ regulation of arthritic microenvironment based on nanomotor strategy is proposed for active RA therapy. The synthesized MnO2‐motors enable catalytic regulation of RA microenvironment by consuming the overproduced H2O2 and generating O2 synergistically. The generated O2 under H2O2‐rich conditions functions as inflammation detector, propellant for enhanced diffusion, as well as ameliorator for the hypoxic synovial microenvironment. Owing to O2 generation and inflammation scavenging, the MnO2‐motors block the re‐polarization of pro‐inflammatory macrophages, which results in significantly decreased secretion of multiple pro‐inflammatory cytokines both in vitro and in vivo. In addition, intra‐articular administration of MnO2‐motors to collagen‐induced arthritis rats (CIA rats) effectively alleviates hypoxia, synovial inflammation, bone erosion, and cartilage degradation in joints. Therefore, the proposed arthritic regulation strategy shows great potential to seamlessly integrate basic research of RA with clinical translation.
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影响因子：
10.2
作者：
Liu, Junzhao;Wu, Zuohong;Liu, Yadong;Zhan, Zhu;Yang, Liping;Wang, Can;Jiang, Qinqin;Ran, Haitao;Li, Pan;Wang, Zhigang
通讯作者：
Wang, Zhigang
影响因子：
4.7
作者：
Choi SH;Aid S;Kim HW;Jackson SH;Bosetti F
通讯作者：
Bosetti F
肿瘤微环境自激活纳米级金属有机框架用于基于铁死亡的癌症化学动力学/光热/化疗治疗
DOI：
10.1016/j.apsb.2021.01.016
发表时间：
2021-10
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Liang Y;Zhang L;Peng C;Zhang S;Chen S;Qian X;Luo W;Dan Q;Ren Y;Li Y;Zhao B
通讯作者：
Zhao B
影响因子：
29.4
作者：
Chen, Qian;Feng, Liangzhu;Liu, Zhuang
通讯作者：
Liu, Zhuang
影响因子：
15
作者：
Gu, Zhengying;Liu, Tianqing;Yu, Chengzhong
通讯作者：
Yu, Chengzhong