Comparison of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus viral load in peripheral blood mononuclear cells and oral fluids of HIV-negative individuals aged 3-89 years from Uganda.
Comparison of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus viral load in peripheral blood mononuclear cells and oral fluids of HIV-negative individuals aged 3-89 years from Uganda.
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DOI：
10.1186/s13027-023-00516-9
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发表时间：
2023-06-14
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
我们之前发现乌干达个体的年龄、性别和疟疾与 KSHV 相关。在这项研究中，我们评估了相同样本中与 EBV 相关的相同因素。总体而言，74%（口腔液）和 46%（PBMC）可检测到 EBV。这明显高于 KSHV 观察到的情况（24% 口腔液和 11% PBMC）。 PBMC 中携带 EBV 的个体更有可能在 PBMC 中携带 KSHV (P = 0.011)。口腔液中检测 EBV 的高峰年龄为 3-5 岁，而 KSHV 的高峰年龄为 6-12 岁。在 PBMC 中，EBV 检测存在双峰年龄峰值（3-5 岁和 66+岁），而 KSHV 则在 3-5 岁出现单峰。与疟疾阴性个体相比，患有疟疾的个体 PBMC 中 EBV 水平较高（P = 0.002）。总之，我们的结果表明，年龄较小和疟疾与 PBMC 中较高水平的 EBV 和 KSHV 相关，表明疟疾影响对两种 γ-疱疹病毒的免疫力。在线版本包含可在 10.1186/s13027-023-00516-9 获取的补充材料。
We previously found that age, sex and malaria were associated with KSHV in individuals from Uganda. In this study, we have evaluated these same factors in relation to EBV in the same specimens. Overall, 74% (oral fluids) and 46% (PBMCs) had detectable EBV. This was significantly higher than observed for KSHV (24% oral fluids and 11% PBMCs). Individuals with EBV in PBMCs were more likely to have KSHV in PBMCs (P = 0.011). The peak age for detection of EBV in oral fluids was 3–5 years while that of KSHV was 6–12 years. In PBMCs, there was a bimodal peak age for detection of EBV (at 3–5 years and 66 + years) while for KSHV there was a single peak at 3–5 years. Individuals with malaria had higher levels of EBV in PBMCs compared to malaria-negative individuals (P = 0.002). In summary, our results show that younger age and malaria are associated with higher levels of EBV and KSHV in PBMCs suggesting malaria impacts immunity to both gamma-herpesviruses. The online version contains supplementary material available at 10.1186/s13027-023-00516-9.
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影响因子：
2.3
作者：
Daud II;Ogolla S;Amolo AS;Namuyenga E;Simbiri K;Bukusi EA;Ng'ang'a ZW;Ploutz-Snyder R;Sumba PO;Dent A;Rochford R
通讯作者：
Rochford R
影响因子：
5.4
作者：
Summerauer AM;Jäggi V;Ogwang R;Traxel S;Colombo L;Amundsen E;Eyer T;Subramanian B;Fehr J;Mantel PY;Idro R;Bürgler S
通讯作者：
Bürgler S
DOI：
10.1098/rstb.2016.0275
发表时间：
2017-10-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Mariggiò G;Koch S;Schulz TF
通讯作者：
Schulz TF
影响因子：
6.7
作者：
Labo N;Miley W;Marshall V;Gillette W;Esposito D;Bess M;Turano A;Uldrick T;Polizzotto MN;Wyvill KM;Bagni R;Yarchoan R;Whitby D
通讯作者：
Whitby D
影响因子：
64.5
作者：
Robbiani DF;Bothmer A;Callen E;Reina-San-Martin B;Dorsett Y;Difilippantonio S;Bolland DJ;Chen HT;Corcoran AE;Nussenzweig A;Nussenzweig MC
通讯作者：
Nussenzweig MC