Plasmodium falciparum infection is associated with Epstein-Barr virus reactivation in pregnant women living in malaria holoendemic area of Western Kenya.
Plasmodium falciparum infection is associated with Epstein-Barr virus reactivation in pregnant women living in malaria holoendemic area of Western Kenya.
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DOI：
10.1007/s10995-014-1546-4
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发表时间：
2015-03
影响因子：
2.3
通讯作者：
Rochford R
中科院分区：
文献类型：
--
作者：
Daud II;Ogolla S;Amolo AS;Namuyenga E;Simbiri K;Bukusi EA;Ng'ang'a ZW;Ploutz-Snyder R;Sumba PO;Dent A;Rochford R
恶性疟原虫疟疾在婴儿早期 EBV 传播中的作用仍然难以捉摸。我们假设怀孕期间感染疟疾可能会导致 EBV 重新激活，从而导致循环中 EBV 载量较高，从而导致 EBV 感染的年龄提前。恶性疟原虫疟疾全流行的基苏木的孕妇每月通过产前检查（每位母亲最多 4 次）和分娩进行积极随访。使用实时定量 (Q) – PCR，我们量化并比较了患有和未患有恶性疟原虫疟疾的孕妇血液中的 EBV 和恶性疟原虫 DNA 水平。怀孕期间检测到疟疾的孕妇比怀孕期间没有感染疟疾证据的孕妇更有可能检测到 EBV DNA（64% vs. 36%，p=0.01）。通过量化纵向观察曲线下面积 (AUC) 进行分析，无论妊娠孕龄如何，患有恶性疟原虫疟疾的孕妇的 EBV 载量显着高于没有疟疾感染证据的孕妇 (p = 0.01)。疟疾负荷的增加与 EBV 负荷的增加相关 (p <0.0001)。妊娠晚期的 EBV 载量高于妊娠早期和中期，与已知感染无关。与怀孕期间没有恶性疟原虫感染证据的女性相比，患有疟疾的孕妇的 EBV 载量显着更高且升高。怀孕期间感染恶性疟原虫后 EBV 潜伏期失去控制以及随后循环中 EBV 负荷的增加可能导致产后母亲唾液和母乳中 EBV 的脱落增加，但还需要进一步研究。
The role of Plasmodium falciparum malaria in EBV transmission among infants early in life remain elusive. We hypothesized that infection with malaria during pregnancy could cause EBV reactivation leading to high EBV load in circulation, which could subsequently enhance early age of EBV infection. Pregnant women in Kisumu, where P. falciparum malaria is holoendemic, were actively followed monthly through antenatal visits (up to 4 per mother) and delivery. Using real-time quantitative (Q) – PCR, we quantified and compared EBV and P. falciparum DNA levels in the blood of pregnant women with and without P. falciparum malaria. Pregnant women that had malaria detected during pregnancy were more likely to have detectable EBV DNA than pregnant women who had no evidence of malaria infection during pregnancy (64% vs. 36%, p=0.01). EBV load as analyzed by quantifying area under the longitudinal observation curve (AUC) was significantly higher in pregnant women with P. falciparum malaria than in women without evidence of malaria infection (p =0.01) regardless of gestational age of pregnancy. Increase in malaria load correlated with increase in EBV load (p <0.0001). EBV load was higher in third trimester (p =0.04) than first and second trimester of pregnancy independent of known infections. Significantly higher frequency and elevated EBV loads were found in pregnant women with malaria than in women without evidence of P. falciparum infection during pregnancy. The loss of control of EBV latency following P. falciparum infection during pregnancy and subsequent increase in EBV load in circulation could contribute to enhanced shedding of EBV in maternal saliva and breast milk postpartum, but further studies are needed.
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影响因子：
168.9
作者：
LAM, KMC;SYED, N;CRAWFORD, DH
通讯作者：
CRAWFORD, DH
影响因子：
6.4
作者：
Adegnika, Ayola A.;Koehler, Carsten;Yazdanbakhsh, Maria
通讯作者：
Yazdanbakhsh, Maria
影响因子：
9.4
作者：
Kamau, Edwin;Tolbert, LaDonna S.;Ockenhouse, Christian F.
通讯作者：
Ockenhouse, Christian F.
影响因子：
6.4
作者：
BIGGAR, RJ;HENLE, G;HENLE, W
通讯作者：
HENLE, W
DOI：
10.1080/713605925
发表时间：
2003-06-01
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Baschat, A A;Towbin, J;Weiner, C P
通讯作者：
Weiner, C P