Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models.

Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models.
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DOI:
10.1538/expanim.17-0153
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发表时间:
2018-05-10
影响因子:
2.4
通讯作者:
Ikawa M
Ikawa M
中科院分区:
医学4区
文献类型:
--
作者:
Fujihara Y;Miyata H;Ikawa M

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哺乳动物的受精由许多步骤组成,包括精子在子宫中的存活、精子在女性生殖道中的迁移、精子的生理和形态变化以及输卵管中的精卵相互作用。半个多世纪以来,体外研究已经揭示了这些受精步骤的重要因素。然而,受精的分子机制最近因转基因动物的出现而被修改。在这里,我们重点关注精子受精能力的重要因素,并描述我们在哺乳动物受精机制,特别是精子从子宫迁移到输卵管的机制方面的最新进展。
Mammalian fertilization is comprised of many steps including sperm survival in the uterus, sperm migration in the female reproductive tract, physiological and morphological changes to the spermatozoa, and sperm-egg interaction in the oviduct. In vitro studies have revealed essential factors for these fertilization steps for over half a century. However, the molecular mechanism of fertilization has recently been revised by the emergence of genetically modified animals. Here, we focus on essential factors for sperm fertilizing ability and describe recent advances in our knowledge of the mechanisms of mammalian fertilization, especially of sperm migration from the uterus into the oviduct.
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