Disease burden in patients with severe hand, foot, and mouth disease in Jiangsu Province: a cross-sectional study.
Disease burden in patients with severe hand, foot, and mouth disease in Jiangsu Province: a cross-sectional study.
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DOI：
10.1080/21645515.2022.2049168
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发表时间：
2022-11-30
影响因子：
4.8
通讯作者：
Jin, Hui
中科院分区：
文献类型：
--
作者：
Han, Ying;Ji, Hong;Shen, Wenqi;Duan, Chunxiao;Cui, Tingting;Chen, Liling;Hang, Hui;Zhang, Zhong;Sun, Hongmin;Zhang, Xuefeng;Jin, Hui
本研究旨在评估中国江苏省重症手足口病（HFMD）患者的疾病负担和健康相关生活质量（HRQOL）。我们分析了2009年至2020年江苏省手足口病病例的监测数据。此外，2017年1月至2018年5月在中国南京和苏州进行了一项横断面研究。从选定的医院招募了重症手足口病患者及其家长。使用调查问卷和医院管理系统来收集有关直接经济负担的数据。使用 TNO-AZL 学前生活质量 (TAPQOL) 量表评估儿童的 HRQOL。 2009-2020年，江苏省国家卫生计生委共报告手足口病确诊病例1,348,737例。其中，重症病例 9,622 例，其中 62 例 (0.64%) 死亡。 2017年1月至2018年5月，采用结构化调查问卷收集了362例重症手足口病病例的数据。人均直接经济负担中位数为16142.88元，与地区、住院时间相关（P < .05）。 2017年至2018年，江苏省所有重症手足口病病例直接经济负担约为1664万元。最后，重症手足口病儿童TAPQOL量表的中位数（IQR）为69.23（56.20，82.27）。严重的手足口病感染对个人来说是一个相对较大的负担，而EV-A71感染对人群的负担甚至更大。重症手足口病的预防应加强卫生习惯，并有针对性地接种EV-A71疫苗。
This study aimed to estimate the disease burden and health-related quality of life (HRQOL) among patients with severe hand, foot, and mouth disease (HFMD) in Jiangsu Province, China. We analyzed the surveillance data of HFMD cases in Jiangsu Province from 2009 to 2020. Moreover, a cross-sectional study was conducted in Nanjing and Suzhou, China, between January 2017 and May 2018. Patients with severe HFMD and their parents were recruited from selected hospitals. Questionnaires and hospital management systems were used to collect data on direct economic burden. The HRQOL of children was assessed using the TNO-AZL Preschool Quality of Life (TAPQOL) scale. A total of 1,348,737 confirmed cases of HFMD were reported to the NNDRS in Jiangsu province during 2009–2020. Of these, 9,622 were severe cases, with 62 (.64%) of these being fatal. From January 2017 to May 2018, data was collected from 362 severe HFMD cases using a structured questionnaire. The median per capita direct economic burden was RMB 16142.88, and was associated with the region and length of hospital stay (P < .05). The direct economic burden for all cases of severe HFMD in Jiangsu province between 2017 and 2018 was approximately RMB 16.64 million. Finally, the median (IQR) of the TAPQOL scale for children with severe HFMD was 69.23 (56.20, 82.27). Severe HFMD infection is a relatively large burden for individuals, and the burden of EV-A71 infection was seen to be even greater for the population. Prevention of severe HFMD should strengthen hygiene habits and targeted measures for EV-A71 vaccination.
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影响因子：
11.8
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