Epidemiological characteristics of hand, foot, and mouth disease in Yunnan Province, China, 2008-2019.
Epidemiological characteristics of hand, foot, and mouth disease in Yunnan Province, China, 2008-2019.
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云南省手足口病流行病学特征，中国，2008-2019年。
DOI：
10.1186/s12879-021-06462-4
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发表时间：
2021-08-04
影响因子：
3.7
通讯作者：
Huang T
中科院分区：
文献类型：
--
作者：
Jiang L;Jiang H;Tian X;Xia X;Huang T
自2016年以来，肠道病毒71型（EV 71）疫苗已被批准进入市场，但对于云南省引入疫苗对手足口病（HFMD）流行病学的影响知之甚少。本研究描述了EV 71疫苗接种前后云南省手足口病的流行病学特征。分析了2008年至2019年间收集的监测数据，以得出病例的流行病学分布、病原学组成和EV 71疫苗接种覆盖率，并比较EV 71疫苗接种前后的这些特征。2016年至2019年，云南共有1，653，533名儿童接种了EV 71疫苗。≤5岁儿童EV 71疫苗接种率为5.53%~ 15.01%。在EV 71疫苗引入后，手足口病的总体发病率增加，并在2018年和2019年达到每10万人口年200多例。但病例严重度和病死率有所下降，2016年后分别保持在1%和0.005%以下。EV 71相关的轻度、重度和致命病例急剧减少。结果表明，全省主要肠道病毒血清型均为非EV 71/非CV-A16型。非EV 71/非CV-A16型肠道病毒成为优势毒株，导致云南省肠道病毒感染率较高。扩大EV 71疫苗接种和加强实验室监测可以进一步减少重症手足口病的负担，并检测和监测新出现的肠道病毒。在线版本包含补充材料，可通过10.1186/s12879-021-06462-4获得。
Since 2016, enterovirus 71 (EV71) vaccines have been approved for market entry, and little is known about how the epidemiology of hand, foot, and mouth disease (HFMD) has been affected by the introduction of the vaccines in Yunnan Province. The study describes the epidemiological characteristics of HFMD before and after the introduction of EV71 vaccination in Yunnan Province. Surveillance data collected between 2008 and 2019 were analyzed to produce epidemiological distribution on cases, etiologic composition, and EV71 vaccination coverage, as well as to compare these characteristics before and after EV71 vaccination. A total of 1,653,533 children received EV71 vaccines from 2016 through 2019 in Yunnan. The annual EV71 vaccination coverage rate ranged from 5.53 to 15.01% among children ≤5 years old. After the introduction of EV71 vaccines, the overall incidence of HFMD increased and reached over 200 cases per 100,000 population-years in 2018 and 2019. However, the case severity and case fatality rate decreased and remained lower than 1 and 0.005% after 2016, respectively. EV71-associated mild, severe and fatal cases sharply decreased. The predominant viral serotype changed to non-EV71/non-CV-A16 enteroviruses which were detected across the whole province. Non-EV71/non-CV-A16 enteroviruses became the predominant strain and led to a higher incidence in Yunnan. Expanding EV71 vaccination and strengthening laboratory-based surveillance could further decrease the burden of severe HFMD and detect and monitor emerging enteroviruses. The online version contains supplementary material available at 10.1186/s12879-021-06462-4.
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影响因子：
13.2
作者：
Wang J;Teng Z;Cui X;Li C;Pan H;Zheng Y;Mao S;Yang Y;Wu L;Guo X;Zhang X;Zhu Y
通讯作者：
Zhu Y
DOI：
10.2807/1560-7917.es.2017.22.50.16-00824
发表时间：
2017-12
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Yang B;Liu F;Liao Q;Wu P;Chang Z;Huang J;Long L;Luo L;Li Y;Leung GM;Cowling BJ;Yu H
通讯作者：
Yu H
DOI：
10.12659/msm.901364
发表时间：
2017-05-25
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Weng Y;Chen W;He W;Huang M;Zhu Y;Yan Y
通讯作者：
Yan Y
影响因子：
12.7
作者：
Du, Zengqing;Zhao, Yilin;Ma, Shaohui
通讯作者：
Ma, Shaohui
DOI：
10.3390/v7122947
发表时间：
2015-12-07
期刊：
Viruses
影响因子：
--
作者：
Zhuang ZC;Kou ZQ;Bai YJ;Cong X;Wang LH;Li C;Zhao L;Yu XJ;Wang ZY;Wen HL
通讯作者：
Wen HL