Brain-derived neurotrophic factor in the airways.
Brain-derived neurotrophic factor in the airways.
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DOI：
10.1016/j.pharmthera.2014.02.006
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发表时间：
2014-07
影响因子：
13.5
通讯作者：
Martin, Richard J.
中科院分区：
文献类型：
--
作者：
Prakash, Y. S.;Martin, Richard J.
除了在神经系统中的众所周知的作用外，人们越来越认识到神经营养因子（例如脑源性神经营养因子（BDNF））及其受体在包括肺在内的外周组织中表达，因此可能有助于多种疾病的正常生理学和病理生理学。该生长因子家族的相关性在于新出现的临床数据表明神经营养素水平和功能在一系列疾病中发生改变，包括新生儿和成人哮喘、鼻窦炎、流感和肺癌。当前的综述重点关注：1）BDNF 表达和信号机制在早期气道和肺部发育中的重要性，对于正常新生儿肺功能及其对早产和炎症和感染等损伤的破坏至关重要； 2) BDNF（可能源自气道神经）如何调节气道张力的神经源性控制，气道张力是气道反射以及对过敏性炎症的功能失调反应的关键方面； 3）新的观点认为，上皮和气道平滑肌等常驻气道细胞产生的局部 BDNF 有助于正常气道结构和功能，以及哮喘等疾病中的气道高反应性和重塑。此外，鉴于 BDNF 在气道中的多效作用，BDNF 可能是一个新颖且有吸引力的治疗靶点。
In addition to their well-known roles in the nervous system, there is increasing recognition that neurotrophins such as brain derived neurotrophic factor (BDNF) as well as their receptors are expressed in peripheral tissues including the lung, and can thus potentially contribute to both normal physiology and pathophysiology of several diseases. The relevance of this family of growth factors lies in emerging clinical data indicating altered neurotrophin levels and function in a range of diseases including neonatal and adult asthma, sinusitis, influenza, and lung cancer. The current review focuses on 1) the importance of BDNF expression and signaling mechanisms in early airway and lung development, critical to both normal neonatal lung function and also its disruption in prematurity and insults such as inflammation and infection; 2) how BDNF, potentially derived from airway nerves modulate neurogenic control of airway tone, a key aspect of airway reflexes as well as dysfunctional responses to allergic inflammation; 3) the emerging idea that local BDNF production by resident airway cells such as epithelium and airway smooth muscle can contribute to normal airway structure and function, and to airway hyperreactivity and remodeling in diseases such as asthma. Furthermore, given its pleiotropic effects in the airway, BDNF may be a novel and appealing therapeutic target.
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DOI：
10.1002/neu.480251107
发表时间：
1994-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BARBACID, M
通讯作者：
BARBACID, M
影响因子：
2.8
作者：
Braun, A;Lommatzsch, M;Renz, H
通讯作者：
Renz, H
DOI：
10.1165/rcmb.2010-0195oc
发表时间：
2011-10-01
影响因子：
6.4
作者：
Avcuoglu, Sibel;Wygrecka, Malgorzata;Kwapiszewska, Grazyna
通讯作者：
Kwapiszewska, Grazyna
DOI：
10.1111/j.1749-6632.1995.tb26693.x
发表时间：
1995-01-01
期刊：
RECEPTOR ACTIVATION BY ANTIGENS, CYTOKINES, HORMONES, AND GROWTH FACTORS
影响因子：
--
作者：
Barbacid, M
通讯作者：
Barbacid, M
影响因子：
3.8
作者：
Andiappan, Anand Kumar;Parate, Pallavi Nilkanth;Chew, Fook Tim
通讯作者：
Chew, Fook Tim