Hippocampal morphology mediates biased memories of chronic pain.
Hippocampal morphology mediates biased memories of chronic pain.
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DOI：
10.1016/j.neuroimage.2017.10.030
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发表时间：
2018-02-01
期刊：
影响因子：
5.7
通讯作者：
Apkarian AV
中科院分区：
文献类型：
--
作者：
Berger SE;Vachon-Presseau É;Abdullah TB;Baria AT;Schnitzer TJ;Apkarian AV
经验和记忆往往是不匹配的。虽然多项研究已经调查了情绪事件回忆错误的心理基础，但在慢性疼痛领域，经验和记忆之间分歧的神经生物学机制仍然相对未被探索。在这里，我们研究了经验的慢性下腰痛（CBP）强度（每天两次评级）和记忆的疼痛强度（n = 48名受试者）相对于心理测量学特性，海马形态，记忆能力和人格特质奖励之间的差异。77%的CBP患者夸大了记忆中的疼痛，这取决于他们经历的最强烈的疼痛和他们最近的情绪评级。这种偏差持续了近1年，并与奖励记忆偏差和损失厌恶有关。左后海马特定区域的形状位移介导了疼痛记忆偏差的个性效应，预测了验证CBP组（n = 21）的疼痛记忆偏差，并占疼痛记忆偏差方差的55%。在两个独立组（n = 20/组）中，该区域的形态随时间推移保持稳定，不受慢性疼痛发展的影响。这些结果意味着，一个本地化的海马电路，与奖励处理相关的人格特质，在很大程度上决定了夸大慢性疼痛患者的日常疼痛经历。
Experiences and memories are often mismatched. While multiple studies have investigated psychological underpinnings of recall error with respect to emotional events, the neurobiological mechanisms underlying the divergence between experiences and memories remain relatively unexplored in the domain of chronic pain. Here we examined the discrepancy between experienced chronic low back pain (CBP) intensity (twice daily ratings) and remembered pain intensity (n = 48 subjects) relative to psychometric properties, hippocampus morphology, memory capabilities, and personality traits related to reward. 77% of CBP patients exaggerated remembered pain, which depended on their strongest experienced pain and their most recent mood rating. This bias persisted over nearly 1 year and was related to reward memory bias and loss aversion. Shape displacement of a specific region in the left posterior hippocampus mediated personality effects on pain memory bias, predicted pain memory bias in a validation CBP group (n = 21), and accounted for 55% of the variance of pain memory bias. In two independent groups (n = 20/group), morphology of this region was stable over time and unperturbed by the development of chronic pain. These results imply that a localized hippocampal circuit, and personality traits associated with reward processing, largely determine exaggeration of daily pain experiences in chronic pain patients.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
DOI：
10.1080/13803390490515540
发表时间：
2004-11-01
影响因子：
2.2
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
Apkarian, A. Vania
影响因子：
7.4
作者：
KENT, G
通讯作者：
KENT, G
影响因子：
14.5
作者：
Hashmi, Javeria A.;Baliki, Marwan N.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania