Modeling general proteostasis: proteome balance in health and disease.
Modeling general proteostasis: proteome balance in health and disease.
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DOI：
10.1016/j.ceb.2010.11.001
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发表时间：
2011-04
影响因子：
7.5
通讯作者：
Balch, William E.
中科院分区：
文献类型：
--
作者：
Roth, Daniela M.;Balch, William E.
Protein function is generated and maintained by the proteostasis network (PN) (Balch et al. (2008) Science, 319:916). The PN is a modular, yet integrated system unique to each cell type that is sensitive to signaling pathways that direct development and aging, and respond to folding stress. Mismanagement of protein folding and function triggered by genetic, epigenetic, and environmental causes poses a major challenge to human health and lifespan. Herein, we address the impact of proteostasis defined by the FoldFx model on our understanding of protein folding and function in biology. FoldFx describes how general proteostasis control (GPC) enables the polypeptide chain sequence to achieve functional balance in the context of the cellular proteome. By linking together the chemical and energetic properties of the protein fold with the composition of the PN we discuss the principle of the proteostasis boundary (PB) as a key component of GPC. The curved surface of the PB observed in 3-dimensional space suggests that the polypeptide chain sequence and the PN operate as an evolutionarily conserved functional unit to generate and sustain protein dynamics required for biology. Modeling general proteostasis provides a rational basis for tackling some of the most challenging diseases facing mankind in the 21st century.
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影响因子：
11.1
作者：
He C;Klionsky DJ
通讯作者：
Klionsky DJ
DOI：
10.1038/nrd2760
发表时间：
2009-01
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1007/978-1-4020-6554-5_12
发表时间：
2008-01-01
期刊：
PROGRAMMED CELL DEATH IN CANCER PROGRESSION AND THERAPY
影响因子：
--
作者：
Chauhan, Dharminder;Hideshima, Tern;Anderson, Kenneth C.
通讯作者：
Anderson, Kenneth C.
影响因子：
3.5
作者：
Kumar, Pravir;Ambasta, Rashmi K.;Querfurth, Henry W.
通讯作者：
Querfurth, Henry W.
影响因子：
14.8
作者：
Hutt DM;Herman D;Rodrigues AP;Noel S;Pilewski JM;Matteson J;Hoch B;Kellner W;Kelly JW;Schmidt A;Thomas PJ;Matsumura Y;Skach WR;Gentzsch M;Riordan JR;Sorscher EJ;Okiyoneda T;Yates JR 3rd;Lukacs GL;Frizzell RA;Manning G;Gottesfeld JM;Balch WE
通讯作者：
Balch WE