High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes.
High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes.
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DOI：
10.3390/nu13114123
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发表时间：
2021-11-17
期刊：
影响因子：
5.9
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Du X;Yu L;Ling S;Xie J;Chen W
盐，通常被称为氯化钠，是人体需要的一种重要成分，相对少量。然而，摄入过多的盐会导致高血压，心脏病，甚至扰乱昼夜节律。昼夜节律的生物学过程首先在黑腹果蝇中进行了研究，并得到了很好的理解。在灯光打开和关闭之前，它们的运动活动逐渐增加，这种现象称为预期。在之前的研究中，我们发现高盐饮食（HSD）会损害果蝇的早晨预期行为。在这里，我们发现HSD并没有显著破坏果蝇头部的时钟基因振荡，也没有破坏时钟神经元或外周组织中的PERIOD蛋白振荡。值得注意的是，我们发现，HSD损害神经元可塑性的轴突投射昼夜节律起搏神经元。有趣的是，我们发现PDF神经元的兴奋性增加模拟了HSD，这导致了早晨预期障碍。此外，我们发现HSD显著破坏了大脑中与神经递质相关的生物过程。总之，我们的数据表明，HSD影响神经元的多种功能，并损害生理行为。
Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was first studied in Drosophila melanogaster and is well understood. Their locomotor activity gradually increases before the light is switched on and off, a phenomenon called anticipation. In a previous study, we showed that a high-salt diet (HSD) impairs morning anticipation behavior in Drosophila. Here, we found that HSD did not significantly disrupt clock gene oscillation in the heads of flies, nor did it disrupt PERIOD protein oscillation in clock neurons or peripheral tissues. Remarkably, we found that HSD impairs neuronal plasticity in the axonal projections of circadian pacemaker neurons. Interestingly, we showed that increased excitability in PDF neurons mimics HSD, which causes morning anticipation impairment. Moreover, we found that HSD significantly disrupts neurotransmitter-related biological processes in the brain. Taken together, our data show that an HSD affects the multiple functions of neurons and impairs physiological behaviors.
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影响因子：
--
作者：
Guo CP;Wei Z;Huang F;Qin M;Li X;Wang YM;Wang Q;Wang JZ;Liu R;Zhang B;Li HL;Wang XC
通讯作者：
Wang XC
生长素诱导的降解系统能够在黑腹果蝇的神经系统中条件性地消耗 PERIOD 蛋白。
DOI：
10.1111/febs.14677
发表时间：
2018-12
期刊：
The FEBS journal
影响因子：
--
作者：
Chen W;Werdann M;Zhang Y
通讯作者：
Zhang Y
影响因子：
25
作者：
Faraco G;Brea D;Garcia-Bonilla L;Wang G;Racchumi G;Chang H;Buendia I;Santisteban MM;Segarra SG;Koizumi K;Sugiyama Y;Murphy M;Voss H;Anrather J;Iadecola C
通讯作者：
Iadecola C
影响因子：
64.8
作者：
Grima, B;Chèlot, E;Rouyer, F
通讯作者：
Rouyer, F
影响因子：
4.4
作者：
Grandner MA;Jackson N;Gerstner JR;Knutson KL
通讯作者：
Knutson KL