Estimating the rate of retinal ganglion cell loss in glaucoma.
Estimating the rate of retinal ganglion cell loss in glaucoma.
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DOI：
10.1016/j.ajo.2012.04.022
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发表时间：
2012-11
影响因子：
4.2
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Medeiros FA;Zangwill LM;Anderson DR;Liebmann JM;Girkin CA;Harwerth RS;Fredette MJ;Weinreb RN
提出并评价一种结合结构和功能测量来估计青光眼视网膜神经节细胞(RGC)损失率的新方法。观察队列研究本研究包括213例(213只眼)青光眼患者，采用标准自动视野检查(SAP)和光学相干断层扫描(OCT)进行了平均4.5±0.8年的随访。对照组33名青光眼患者的33只眼在短时间内重复测试，以测试该方法的特异性。对52名健康受试者的52只眼进行了平均4.0±0.7年的随访，以评估与年龄相关的视网膜节细胞的丢失。RGC计数的估计是从SAP和OCT获得的，并使用加权平均来获得每只眼的RGC数量的最终估计。使用线性回归计算每只眼的RGC丢失率。进展的定义是统计上显著的斜率快于年龄预期的视网膜节细胞丧失。在213只眼中，47只眼(22.1%)的RGC丢失率高于预期年龄。与SAP(8.5%)或OCT(14.6%；P<；0.01)的单独参数相比，青光眼基于RGC损失率出现进展的比例更大，而在稳定组中保持类似的特异性。结合结构和功能估计的RGC损失率在检测进行性青光眼损害方面比单独的结构或功能指标表现得更好。
To present and evaluate a new method of estimating rates of retinal ganglion cell (RGC) loss in glaucoma by combining structural and functional measurements. Observational cohort study The study included 213 eyes of 213 glaucoma patients followed for an average of 4.5±0.8 years with standard automated perimetry (SAP) visual fields and optical coherence tomography (OCT). A control group of 33 eyes of 33 glaucoma patients had repeated tests over a short period of time to test the specificity of the method. An additional group of 52 eyes from 52 healthy subjects followed for an average of 4.0±0.7 years was used to estimate age-related losses of RGCs. Estimates of RGC counts were obtained from SAP and OCT and a weighted average was used to obtain a final estimate of the number of RGCs for each eye. The rate of RGC loss was calculated for each eye using linear regression. Progression was defined by a statistically significant slope faster than the age-expected loss of RGCs. From the 213 eyes, 47 (22.1%) showed rates of RGC loss that were faster than the age-expected decline. A larger proportion of glaucomatous eyes showed progression based on rates of RGC loss than based on isolated parameters from SAP (8.5%) or OCT (14.6%; P<0.01), while maintaining similar specificities in the stable group. The rate of RGC loss estimated from combining structure and function performed better than either isolated structural or functional measures for detecting progressive glaucomatous damage.
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影响因子：
4.4
作者：
Medeiros FA;Zangwill LM;Alencar LM;Bowd C;Sample PA;Susanna R Jr;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
1.8
作者：
Malik, Rizwan;Swanson, William H.;Garway-Heath, David F.
通讯作者：
Garway-Heath, David F.
影响因子：
13.7
作者：
Fayers, Tessa;Strouthidis, Nicholas G.;Garway-Heath, David F.
通讯作者：
Garway-Heath, David F.
影响因子：
4.4
作者：
Strouthidis, Nicholas G.;Scott, Andrew;Garway-Heath, David F.
通讯作者：
Garway-Heath, David F.
影响因子：
4.4
作者：
Artes, Paul H.;O'Leary, Neil;Chauhan, Balwantray C.
通讯作者：
Chauhan, Balwantray C.