Child maltreatment and asthma.
Child maltreatment and asthma.
复制标题
DOI：
10.1002/ppul.25982
复制
发表时间：
2022-09
影响因子：
3.1
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
--
作者：
Gaietto, Kristina;Celedon, Juan C.
越来越多的证据表明虐待儿童和哮喘之间存在潜在联系。确定虐待儿童是否以及如何导致或加重哮喘，将对疾病预防和治疗以及公共卫生政策产生重大影响。在这篇文章中，我们审查了儿童虐待和哮喘的流行病学研究和哮喘相关的结果，回顾了儿童虐待和哮喘关联潜在机制的证据，并讨论了未来的方向。到目前为止，大多数针对儿童和成人的研究都报告了儿童虐待与哮喘之间的联系，尽管与哮喘相关的虐待类型在不同的研究中有所不同。这种不一致的发现很可能是由于研究设计和质量的差异造成的。所有研究都受到儿童虐待和选择偏见的潜在漏报，以及对哮喘的不彻底评估的限制。尽管有这些局限性，但流行病学研究的综合证据表明，虐待儿童和哮喘之间可能存在因果联系，尽管各种类型的虐待(身体、性、情感或忽视)的相对贡献尚不清楚。到目前为止，没有足够的证据表明虐待儿童与儿童或成人的肺功能之间存在联系。有限的证据进一步表明，虐待儿童可通过对压力反应、焦虑或抑郁相关障碍、免疫和呼吸道炎症的直接影响以及肥胖风险增加等间接影响，影响哮喘的发展或严重程度。未来的前瞻性研究应该着眼于充分描述虐待儿童和哮喘的特征，同时也评估压力、免疫和治疗反应的相关协变量和生物标记物。
A growing body of evidence suggests a potential link between child maltreatment and asthma. Determining whether and how child maltreatment causes or worsens asthma would have major implications for disease prevention and treatment, as well as public health policy. In this article, we examine epidemiologic studies of child maltreatment and asthma and asthma-related outcomes, review the evidence for potential mechanisms underlying the child maltreatment-asthma association, and discuss future directions. To date, a child maltreatment-asthma link has been reported in most studies of children and adults, though the type of maltreatment associated with asthma has differed across studies. Such discrepant findings are likely explained by differences in study design and quality. All studies have been limited by potential under-reporting of child maltreatment and selection bias, and nonthorough assessment of asthma. Despite these limitations, the aggregate evidence from epidemiologic studies suggests a possible causal link between child maltreatment and asthma, though the relative contributions of various types of maltreatment (physical, sexual, emotional, or neglect) are unclear. To date, there is insufficient evidence of an association between child maltreatment and lung function in children or adults. Limited evidence further suggests that child maltreatment could influence the development or severity of asthma through direct effects on stress responses and anxiety- or depressive-related disorders, immunity, and airway inflammation, as well as indirect effects such as increased obesity risk. Future prospective studies should aim to adequately characterize both child maltreatment and asthma, while also assessing relevant covariates and biomarkers of stress, immune, and therapeutic responses.
登录
查看更多内容
DOI：
10.1164/rccm.201307-1349oc
发表时间：
2014-05-01
影响因子：
24.7
作者：
Brunner, Wendy M.;Schreiner, Pamela J.;Jacobs, David R., Jr.
通讯作者：
Jacobs, David R., Jr.
DOI：
10.1164/rccm.200307-979oc
发表时间：
2004-01-15
影响因子：
24.7
作者：
Forsythe, P;Ebeling, C;Vliagoftis, H
通讯作者：
Vliagoftis, H
DOI：
10.1164/rccm.201605-1067oc
发表时间：
2016-12-01
影响因子：
24.7
作者：
de la Hoz, Rafael E.;Jeon, Yunho;Celedon, Juan C.
通讯作者：
Celedon, Juan C.
影响因子：
14.2
作者：
Coogan, Patricia F.;Wise, Lauren A.;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn
影响因子：
3.3
作者：
Ehrlich, Katherine B.;Miller, Gregory E.;Chen, Edith
通讯作者：
Chen, Edith