Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.
Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women.
复制标题
牛奶，尿液，唾液和血清北卡罗来纳州妇女的邻苯二甲酸盐代谢物的浓度。
DOI：
10.1289/ehp.11610
复制
发表时间：
2009-01
影响因子：
10.4
通讯作者：
Fenton SE
中科院分区：
文献类型：
--
作者：
Hines EP;Calafat AM;Silva MJ;Mendola P;Fenton SE
邻苯二甲酸盐在环境中随处可见，但尚未对哺乳美国妇女在多种介质中的浓度进行评估。这项研究的目的是准确地测量和比较33名北卡罗来纳州哺乳期妇女乳汁和代谢液(血清、唾液和尿液)中邻苯二甲酸单酯氧化代谢产物的浓度。我们用同位素稀释高效液相色谱串联质谱分析了血清、唾液、尿液和牛奶中邻苯二甲酸单(3-羧丙基)、邻苯二甲酸单(2-乙基-5-羧基戊基)、邻苯二甲酸单(2-乙基-5-羟基己基)和邻苯二甲酸单(2-乙基-5-氧己基)代谢物。因为只有尿液没有酯酶，所以我们分析了它的水解性邻苯二甲酸单酯。我们在很少的牛奶(10%)和唾液样本中检测到邻苯二甲酸酯代谢物。MECPP在80%的血清样本中被检测到，但其他代谢物较少见(3-22%)。在85%的≥样本中，10种尿代谢物中有7种可被检测到。尿液中邻苯二甲酸单乙酯的平均浓度最高。代谢物浓度因体液(尿液、血清、牛奶和唾液)不同而不同。问卷数据表明，尿液和/或血清邻苯二甲酸酯代谢产物浓度较高的女性，频繁使用指甲油、免疫球蛋白A以及空腹血糖和甘油三酯水平增加；机动车车龄与某些尿邻苯二甲酸盐浓度呈负相关。我们的数据表明，邻苯二甲酸酯代谢物最常在哺乳期妇女的尿液中检测到，而在血清、牛奶或唾液中较少检测到。尿邻苯二甲酸盐浓度反映的是母体接触，而不代表其他体液，特别是牛奶中氧化代谢物的浓度。
Phthalates are ubiquitous in the environment, but concentrations in multiple media from breast-feeding U.S. women have not been evaluated. The objective of this study was to accurately measure and compare the concentrations of oxidative monoester phthalate metabolites in milk and surrogate fluids (serum, saliva, and urine) of 33 lactating North Carolina women. We analyzed serum, saliva, urine, and milk for the oxidative phthalate metabolites mono(3-carboxypropyl) phthalate, mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) phthalate, and mono(2-ethyl-5-oxohexyl) phthalate using isotope-dilution high-performance liquid chromatography tandem mass spectroscopy. Because only urine lacks esterases, we analyzed it for the hydrolytic phthalate monoesters. We detected phthalate metabolites in few milk (< 10%) and saliva samples. MECPP was detected in > 80% of serum samples, but other metabolites were less common (3–22%). Seven of the 10 urinary metabolites were detectable in ≥ 85% of samples. Monoethyl phthalate had the highest mean concentration in urine. Metabolite concentrations differed by body fluid (urine > serum > milk and saliva). Questionnaire data suggest that frequent nail polish use, immunoglobulin A, and fasting serum glucose and triglyceride levels were increased among women with higher concentrations of urinary and/or serum phthalate metabolites; motor vehicle age was inversely correlated with certain urinary phthalate concentrations. Our data suggest that phthalate metabolites are most frequently detected in urine of lactating women and are less often detected in serum, milk, or saliva. Urinary phthalate concentrations reflect maternal exposure and do not represent the concentrations of oxidative metabolites in other body fluids, especially milk.
登录
查看更多内容
DOI：
10.1016/j.jchromb.2004.02.006
发表时间：
2004-06-05
影响因子：
3
作者：
Calafat, AM;Slakman, AR;Needham, LL
通讯作者：
Needham, LL
影响因子：
5.4
作者：
Duty, SM;Silva, MJ;Hauser, R
通讯作者：
Hauser, R
影响因子：
10.4
作者：
Adibi, Jennifer J;Perera, Frederica P;Jedrychowski, Wieslaw;Camann, David E;Barr, Dana;Jacek, Ryszard;Whyatt, Robin M
通讯作者：
Whyatt, Robin M
DOI：
10.1007/bf00517700
发表时间：
1993-05-01
影响因子：
3
作者：
DIRVEN, HAAM;VANDENBROEK, PHH;JONGENEELEN, FJ
通讯作者：
JONGENEELEN, FJ
影响因子：
6.1
作者：
Koch, HM;Bolt, HM;Angerer, J
通讯作者：
Angerer, J