Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training.
Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training.
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下丘脑-垂体-肾上腺对跑步机运动压力的急性反应。
DOI：
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发表时间：
1987
影响因子：
158.5
通讯作者：
G. Chrousos
中科院分区：
文献类型：
--
作者：
A. Luger;P. Deuster;S. Kyle;W. Gallucci;Lesley C. Montgomery;P. Gold;D. Loriaux;G. Chrousos
为了研究身体调节对下丘脑-垂体-肾上腺轴的影响，我们检查了久坐受试者、中等训练的跑步者和训练有素的跑步者的血浆促肾上腺皮质激素、皮质醇和乳酸对分级跑步机运动水平（最大摄氧量的 50%、70% 和 90%）和静脉注射绵羊促肾上腺皮质激素释放激素（每公斤体重 1 微克）的反应。与久坐的受试者和中等训练的跑步者相比，训练有素的跑步者晚上的促肾上腺皮质激素和皮质醇的基础浓度升高，但乳酸的浓度却没有升高。所有组中运动刺激的 ACTH、皮质醇和乳酸反应相似，并且与运动强度成正比。然而，当针对所施加的绝对工作负荷进行绘制时，这些反应在受过训练的受试者中减弱了。只有训练有素的组的促肾上腺皮质激素和皮质醇对绵羊促肾上腺皮质激素释放激素的反应减弱，这与持续的皮质醇增多症一致。我们得出的结论是，身体调节与响应给定工作量的垂体肾上腺激活减少有关。下丘脑-垂体-肾上腺轴的改变与轻度皮质醇增多症一致，并且与抑郁症和神经性厌食症的发现相似，仅在训练有素的跑步者中发现。这些改变是否代表了对剧烈运动的日常压力的适应性变化，或者是训练有素的运动员的特定性格特征的标志，目前尚不清楚。
To study the effects of physical conditioning on the hypothalamic-pituitary-adrenal axis, we examined the plasma ACTH, cortisol, and lactate responses in sedentary subjects, moderately trained runners, and highly trained runners to graded levels of treadmill exercise (50, 70, and 90 percent of maximal oxygen uptake) and to intravenous ovine corticotropin-releasing hormone (1 microgram per kilogram of body weight). Basal evening concentrations of ACTH and cortisol, but not of lactate, were elevated in highly trained runners as compared with sedentary subjects and moderately trained runners. Exercise-stimulated ACTH, cortisol, and lactate responses were similar in all groups and were proportional to the exercise intensity employed. These responses, however, were attenuated in the trained subjects when plotted against applied absolute workload. Only the highly trained group had diminished responses of ACTH and cortisol to ovine corticotropin-releasing hormone, consistent with sustained hypercortisolism. We conclude that physical conditioning is associated with a reduction in pituitary-adrenal activation in response to a given workload. Alterations of the hypothalamic-pituitary-adrenal axis consistent with mild hypercortisolism and similar to findings in depression and anorexia nervosa were found only in highly trained runners. Whether these alterations represent an adaptive change to the daily stress of strenuous exercise or a marker of a specific personality profile in highly trained athletes is unknown.
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DOI：
10.1210/jcem-64-1-10
发表时间：
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期刊：
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