Motor cortex gates distractor stimulus encoding in sensory cortex.
Motor cortex gates distractor stimulus encoding in sensory cortex.
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DOI：
10.1038/s41467-023-37848-4
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发表时间：
2023-04-13
影响因子：
16.6
通讯作者：
Zagha, Edward
中科院分区：
文献类型：
--
作者：
Zhang, Zhaoran;Zagha, Edward
抑制对干扰刺激的反应是一种基本的认知功能，对于执行目标导向的任务至关重要。一个共同的框架，神经元实施的干扰抑制是衰减的干扰刺激从早期的感觉到高阶处理。然而，细节的本地化和机制的衰减知之甚少。我们训练小鼠选择性地对一个触须场中的目标刺激做出反应，而忽略另一个触须场中的干扰刺激。在专家任务执行过程中，触须运动皮层的光遗传学抑制增加了对分心物触须刺激的反应和检测的整体趋势。在感觉皮层内，胡须运动皮层的光遗传学抑制增强了干扰刺激向目标偏好神经元的传播。单单元分析显示，胡须运动皮层（wMC）去相关的目标和干扰刺激编码的目标偏好的初级躯体感觉皮层（S1）神经元，这可能会提高选择性目标刺激检测下游读者。此外，我们观察到积极的自上而下的调制从wMC到S1，通过差分激活假定的兴奋性和抑制性神经元刺激发作前。总的来说，我们的研究支持运动皮层的感觉选择的贡献，在抑制干扰刺激的行为反应，通过门控干扰刺激在感觉皮层的传播。新皮层可以过滤掉那些让我们偏离目标的刺激。在这里，作者证明了在小鼠的干扰过滤机制，其中从运动皮层到感觉皮层的自上而下的输入阻止干扰刺激的内部传播。
Suppressing responses to distractor stimuli is a fundamental cognitive function, essential for performing goal-directed tasks. A common framework for the neuronal implementation of distractor suppression is the attenuation of distractor stimuli from early sensory to higher-order processing. However, details of the localization and mechanisms of attenuation are poorly understood. We trained mice to selectively respond to target stimuli in one whisker field and ignore distractor stimuli in the opposite whisker field. During expert task performance, optogenetic inhibition of whisker motor cortex increased the overall tendency to respond and the detection of distractor whisker stimuli. Within sensory cortex, optogenetic inhibition of whisker motor cortex enhanced the propagation of distractor stimuli into target-preferring neurons. Single unit analyses revealed that whisker motor cortex (wMC) decorrelates target and distractor stimulus encoding in target-preferring primary somatosensory cortex (S1) neurons, which likely improves selective target stimulus detection by downstream readers. Moreover, we observed proactive top-down modulation from wMC to S1, through the differential activation of putative excitatory and inhibitory neurons before stimulus onset. Overall, our studies support a contribution of motor cortex to sensory selection, in suppressing behavioral responses to distractor stimuli by gating distractor stimulus propagation within sensory cortex. The neocortex can filter out stimuli that distract us from our goals. Here the authors demonstrate in mice a mechanism of distractor filtering, in which top-down inputs from motor cortex to sensory cortex prevents the internal propagation of distractor stimuli.
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