Adaptive, behaviorally gated, persistent encoding of task-relevant auditory information in ferret frontal cortex.
Adaptive, behaviorally gated, persistent encoding of task-relevant auditory information in ferret frontal cortex.
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DOI：
10.1038/nn.2598
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发表时间：
2010-08
影响因子：
25
通讯作者：
Shamma, Shihab A.
中科院分区：
文献类型：
--
作者：
Fritz, Jonathan B.;David, Stephen V.;Radtke-Schuller, Susanne;Yin, Pingbo;Shamma, Shihab A.
来自额叶皮层（FC）的自上而下的信号在感觉加工的认知控制中起着关键作用。为了探索这种相互作用，我们比较了雪貂FC和初级听觉皮层（A1）在听觉和视觉任务需要区分类的参考和目标刺激的活动。FC反应是行为门控的，选择性地编码目标刺激的时间和不变的行为意义，可以快速发作，有时持续数小时后的行为。这反映了A1中的早期发现，即注意力引发了光谱时间感受野的快速，选择性，持续性，任务相关的变化。同时记录的局部场电位（LFPs）显示行为门控变化的区域间的连贯性，选择性调制FC和焦点区域之间的A1响应目标声音。这些结果表明，A1和FC动态地建立了一个功能连接，在听觉行为，形状的感觉信息流，并保持一个持久的跟踪最近的任务相关的刺激功能。
Top-down signals from frontal cortex (FC) are conjectured to play a critical role in cognitive control of sensory processing. To explore this interaction, we compared activity in ferret FC and primary auditory cortex (A1) during auditory and visual tasks requiring discrimination between classes of reference and target stimuli. FC responses were behaviorally-gated, selectively encoded the timing and invariant behavioral meaning of target stimuli, could be rapid in onset, and sometimes persisted for hours following behavior. This mirrors earlier findings in A1that attention triggered rapid, selective, persistent, task-related changes in spectrotemporal receptive fields. Simultaneously recorded local field potentials (LFPs) revealed behaviorally-gated changes in inter-areal coherence, selectively modulated between FC and focal regions of A1 responsive to target sounds. These results suggest that A1 and FC dynamically establish a functional connection during auditory behavior that shapes the flow of sensory information and maintains a persistent trace of recent task-relevant stimulus features.
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DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R
DOI：
10.1523/jneurosci.5249-08.2009
发表时间：
2009-03-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
David SV;Mesgarani N;Fritz JB;Shamma SA
通讯作者：
Shamma SA
影响因子：
25
作者：
Fujisawa, Shigeyoshi;Amarasingham, Asohan;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
DOI：
10.1093/cercor/bhp002
发表时间：
2009-10
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Anton-Erxleben K;Stephan VM;Treue S
通讯作者：
Treue S
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.