Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.
Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.
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DOI：
10.3390/ijms19041259
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发表时间：
2018-04-23
影响因子：
5.6
通讯作者：
Inamura K
中科院分区：
文献类型：
--
作者：
Inamura K
肺癌是全球癌症相关死亡的首要原因，肺腺癌是最常见的肺癌亚型。在所有肺腺癌中，最常见的亚群是通过从非典型腺瘤样增生（AAH）到原位腺癌（AIS），再到微浸润腺癌（MIA），最后到具有贴壁生长模式的明显浸润性腺癌的肿瘤发生和进展过程而形成的。这些肿瘤的临床病理和分子特征支持了这种逐步发展的过程。在2015年世界卫生组织分类中，AAH和AIS都被定义为浸润前病变，而MIA被确定为一种早期浸润性腺癌，如果完全切除则预计不会复发。近期的研究已经对肺腺癌肿瘤发生和进展的分子特征进行了研究。表皮生长因子受体（EGFR）突变的腺癌经常通过多步骤进展过程发展。癌基因诱导的衰老似乎降低了KRAS或BRAF突变腺癌的多步骤进展频率，其肿瘤演变可能与表观遗传改变和激酶失活突变有关。这篇综述总结了早期肺腺癌肿瘤发生和肿瘤进展的当前知识，特别关注其临床病理特征及其与驱动基因突变（EGFR、KRAS和BRAF）的关联，以及其分子发病机制和进展。
Lung cancer is the leading cause of cancer-related deaths worldwide, with lung adenocarcinoma representing the most common lung cancer subtype. Among all lung adenocarcinomas, the most prevalent subset develops via tumorigenesis and progression from atypical adenomatous hyperplasia (AAH) to adenocarcinoma in situ (AIS), to minimally invasive adenocarcinoma (MIA), to overt invasive adenocarcinoma with a lepidic pattern. This stepwise development is supported by the clinicopathological and molecular characteristics of these tumors. In the 2015 World Health Organization classification, AAH and AIS are both defined as preinvasive lesions, whereas MIA is identified as an early invasive adenocarcinoma that is not expected to recur if removed completely. Recent studies have examined the molecular features of lung adenocarcinoma tumorigenesis and progression. EGFR-mutated adenocarcinoma frequently develops via the multistep progression. Oncogene-induced senescence appears to decrease the frequency of the multistep progression in KRAS- or BRAF-mutated adenocarcinoma, whose tumor evolution may be associated with epigenetic alterations and kinase-inactive mutations. This review summarizes the current knowledge of tumorigenesis and tumor progression in early lung adenocarcinoma, with special focus on its clinicopathological characteristics and their associations with driver mutations (EGFR, KRAS, and BRAF) as well as on its molecular pathogenesis and progression.
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影响因子：
64.5
作者：
Heidorn SJ;Milagre C;Whittaker S;Nourry A;Niculescu-Duvas I;Dhomen N;Hussain J;Reis-Filho JS;Springer CJ;Pritchard C;Marais R
通讯作者：
Marais R
DOI：
10.1097/pas.0b013e318190157c
发表时间：
2009-03
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Borczuk AC;Qian F;Kazeros A;Eleazar J;Assaad A;Sonett JR;Ginsburg M;Gorenstein L;Powell CA
通讯作者：
Powell CA
非典型腺瘤增生与原发性肺癌之间的关联。
影响因子：
8.8
作者：
Chapman AD;Kerr KM
通讯作者：
Kerr KM
影响因子：
4.6
作者：
Inamura, Kentaro;Ninomiya, Hironori;Matsubara, Osamu
通讯作者：
Matsubara, Osamu
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J