Previous exposure to hormone replacement therapy and confounders in metabolic studies.
Previous exposure to hormone replacement therapy and confounders in metabolic studies.
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既往接受过激素替代疗法和代谢研究中的混杂因素。
DOI：
10.1097/00042192-200107000-00010
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Poehlman,ET
中科院分区：
文献类型：
--
作者：
Sites,CK;L'Hommedieu,GD;Brochu,M;Poehlman,ET
ObjectiveThe quantity of intra-abdominal fat is highly associated with the development of diabetes mellitus. We sought to determine whether recent hormone replacement therapy (HRT) use modifies central fat and insulin sensitivity in postmenopausal women compared with women who had never used HRT.DesignWe measured intra-abdominal fat, subcutaneous abdominal fat, and sagittal diameter at the L4-L5 vertebral disc space using computed tomography imaging. Total body fat and fat-free mass were measured using dual energy x-ray absorptiometry. Insulin sensitivity was assessed using the euglycemic hyperinsulinemic clamp technique in 42 nonobese postmenopausal women, age 51±4 years (12 recent HRT users plus 30 never-users). All women who were taking HRT discontinued it for 2 months before the study.ResultsAfter statistical adjustment for age, previous use of HRT was associated with decreased intra-abdominal fat (72±34 cm 2) compared with no HRT use (96±33 cm 2; p= 0.05). This difference remained significant after adjustment for time since menopause. When previous HRT users were compared with nonusers, there were no differences in subcutaneous abdominal fat, sagittal diameter, fat-free mass, total fat, insulin sensitivity, or body weight.ConclusionsRecent HRT use is associated with lower intra-abdominal fat in nonobese, early postmenopausal women. This finding suggests a carry-over effect of HRT on intra-abdominal fat. Recent HRT use does not seem to be associated with differences in glucose disposal.
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红外线辐射和白内障。
DOI：
--
发表时间：
1984
期刊：
Acta Ophthalmologica, Supplementum
影响因子：
--
作者：
E. Lydahl
通讯作者：
E. Lydahl
一般人群样本中晶状体核、皮质和后囊下混浊的患病率。
DOI：
--
发表时间：
1984
期刊：
Ophthalmology (Rochester, Minn.)
影响因子：
--
作者：
R. Sperduto;R. Hiller
通讯作者：
R. Hiller
DOI：
10.1093/ajcn/70.4.517
发表时间：
1999-10
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Lisa E. Brown;E. Rimm;J. Seddon;E. Giovannucci;L. Chasan-Taber;D. Spiegelman;W. Willett;S. Hankins
通讯作者：
Lisa E. Brown;E. Rimm;J. Seddon;E. Giovannucci;L. Chasan-Taber;D. Spiegelman;W. Willett;S. Hankins
口服和透皮绝经后雌激素替代疗法对 C 反应蛋白的不同影响
影响因子：
6.7
作者：
K. Lacut;E. Oger;G. Le Gal;M. Blouch;J. Abgrall;V. Kerlan;P. Scarabin;D. Mottier
通讯作者：
D. Mottier
DOI：
10.1016/s1043-4682(10)80007-8
发表时间：
1992-02
期刊：
Seminars in cell biology
影响因子：
--
作者：
D. Goodenough
通讯作者：
D. Goodenough