Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
复制标题
口服和透皮绝经后雌激素替代疗法对 C 反应蛋白的不同影响
DOI：
10.1055/s-0037-1613608
复制
发表时间：
2003
影响因子：
6.7
通讯作者：
D. Mottier
中科院分区：
文献类型：
--
作者：
K. Lacut;E. Oger;G. Le Gal;M. Blouch;J. Abgrall;V. Kerlan;P. Scarabin;D. Mottier
Summary C-reactive protein (CRP) is one of the main independent predictors of cardiovascular events. Oral post-menopausal estro-gen replacement therapy (ERT) increases CRP levels, but the effect of transdermal ERT is not well documented. CRP, interleukine-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were evaluated in a randomised study of 196 healthy postmenopausal women, who were allocated to receive continuous oral estradiol-17β, (n=63) or transdermal estradiol-17β, (n=68) both combined with micronised progesterone, or placebo (n=65). Oral estrogen increased CRP levels compared with both placebo (p=0.010) and transdermal estrogen (p=0.004) at 6 months. There was no significant effect of transdermal estro-gen on CRP levels compared with placebo (p=0.997). No significant difference was found in the median changes for IL-6 and TNF-α between the three treatment groups. In conclusion, transdermal estrogen has no significant effect on CRP levels at 6 months, but CRP concentrations increased significantly with oral estrogen although no changes in cytokine levels were detected. The clinical relevance of these effects remains to be determined.
登录
查看更多内容
影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
影响因子：
5
作者：
Kuller, LH;Tracy, RP;Meilahn, EN
通讯作者：
Meilahn, EN
DOI：
--
发表时间：
1983-04
期刊：
The American journal of pathology
影响因子：
--
作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
通讯作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
DOI：
--
发表时间：
1990-04
期刊：
Molecular biology & medicine
影响因子：
--
作者：
H. Baumann;J. Gauldie
通讯作者：
H. Baumann;J. Gauldie
补体蛋白 C5b-9 诱导内皮质膜形成囊泡，并暴露催化表面以组装凝血酶原酶复合物。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hamilton,KK;Hattori,R;Esmon,CT;Sims,PJ
通讯作者：
Sims,PJ