Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort.
Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort.
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DOI：
10.1136/thoraxjnl-2021-217080
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发表时间：
2022-01
期刊：
影响因子：
10
通讯作者：
Hopewell JC
中科院分区：
文献类型：
--
作者：
Clift AK;von Ende A;Tan PS;Sallis HM;Lindson N;Coupland CAC;Munafò MR;Aveyard P;Hippisley-Cox J;Hopewell JC
关于吸烟与患新冠肺炎的风险及其严重性的相关性，出现了相互矛盾的证据。我们使用英国生物库进行了大规模的观察性和孟德尔随机化(MR)分析。最近的吸烟状况是通过初级保健记录(70.8%)和英国生物库问卷调查数据(29.2%)确定的。新冠肺炎的结果来自英国公共卫生组织的SARS-CoV-2检测数据、住院数据和死亡证明(截至2020年8月18日)。Logistic回归用于评估吸烟状况与确诊的SARS-CoV-2感染、与新冠肺炎相关的住院以及与新冠肺炎相关的死亡之间的关联。使用已建立的遗传工具对吸烟开始和吸烟重度进行了逆方差加权磁共振分析(按SD增加报告)。符合 标准的参与者有421人，确诊感染1,649人，与新冠肺炎相关的住院治疗968人，与新冠肺炎相关的死亡444人。与非吸烟者相比，吸烟者的住院风险(OR 1.80，95%CI 1.26~2.29)和死亡率(吸烟1~9次/天：或2.14，95%CI 0.87~5.24；10~19次/天：或5.91，95%CI 3.66~9.54；20+/天：或6.11，95%CI 3.59~10.42)。在对281名 -105白种英国参与者的MR分析中，基因预测的吸烟倾向与较高的感染风险(OR1.45，95%可信区间1.10至1.91)和住院风险(OR 1.60，95%可信区间1.13至2.27)相关。遗传预测的每天吸烟次数越多，所有结果的风险越高(感染OR 2.51，95%CI 1.20至5.24；住院OR 5.08，95%CI 2.04至12.66；死亡OR 10.02，95%CI 2.53至39.72)。来自两种分析方法的一致结果支持吸烟对严重新冠肺炎风险的因果影响。
Conflicting evidence has emerged regarding the relevance of smoking on risk of COVID-19 and its severity. We undertook large-scale observational and Mendelian randomisation (MR) analyses using UK Biobank. Most recent smoking status was determined from primary care records (70.8%) and UK Biobank questionnaire data (29.2%). COVID-19 outcomes were derived from Public Health England SARS-CoV-2 testing data, hospital admissions data, and death certificates (until 18 August 2020). Logistic regression was used to estimate associations between smoking status and confirmed SARS-CoV-2 infection, COVID-19-related hospitalisation, and COVID-19-related death. Inverse variance-weighted MR analyses using established genetic instruments for smoking initiation and smoking heaviness were undertaken (reported per SD increase). There were 421 469 eligible participants, 1649 confirmed infections, 968 COVID-19-related hospitalisations and 444 COVID-19-related deaths. Compared with never-smokers, current smokers had higher risks of hospitalisation (OR 1.80, 95% CI 1.26 to 2.29) and mortality (smoking 1–9/day: OR 2.14, 95% CI 0.87 to 5.24; 10–19/day: OR 5.91, 95% CI 3.66 to 9.54; 20+/day: OR 6.11, 95% CI 3.59 to 10.42). In MR analyses of 281 105 White British participants, genetically predicted propensity to initiate smoking was associated with higher risks of infection (OR 1.45, 95% CI 1.10 to 1.91) and hospitalisation (OR 1.60, 95% CI 1.13 to 2.27). Genetically predicted higher number of cigarettes smoked per day was associated with higher risks of all outcomes (infection OR 2.51, 95% CI 1.20 to 5.24; hospitalisation OR 5.08, 95% CI 2.04 to 12.66; and death OR 10.02, 95% CI 2.53 to 39.72). Congruent results from two analytical approaches support a causal effect of smoking on risk of severe COVID-19.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1111/1740-9713.01413
发表时间：
2020-08-01
期刊：
Significance (Oxford, England)
影响因子：
--
作者：
Herbert, Annie;Griffith, Gareth;Zuccolo, Luisa
通讯作者：
Zuccolo, Luisa
影响因子：
105.7
作者：
Mansournia, Mohammad Ali;Altman, Douglas G.
通讯作者：
Altman, Douglas G.