Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder.
Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder.
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DOI：
10.1186/s12894-018-0373-0
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发表时间：
2018-06-07
期刊：
影响因子：
2
通讯作者：
Edhi MM
中科院分区：
文献类型：
--
作者：
Hashmi AA;Hussain ZF;Irfan M;Khan EY;Faridi N;Naqvi H;Khan A;Edhi MM
表皮生长因子受体（Epidermal growth factor receptor，EGFR）在多种肿瘤中表达异常，被认为是预后不良的标志物。在我们的人群中没有研究过膀胱癌中过度表达的频率，因此我们的目的是评估EGFR免疫组化表达在局部人群中的频率和预后意义。我们对126例膀胱癌进行了EGFR免疫组化，并评估了EGFR表达与肿瘤分级、固有层浸润、深肌层浸润和疾病复发的关系。EGFR高表达33例（26.2%），低表达19例（15.1%），阴性74例（58.7%）。EGFR表达与肿瘤分级、固有层浸润、深肌层浸润和复发状态显著相关，而与年龄、性别和总生存期无显著相关。Kaplan-Meier曲线显示EGFR表达与复发显著相关，而与总生存期无显著相关性。EGFR过表达与肿瘤分级、固有肌层浸润和复发显著相关，表明其预后价值;因此EGFR可用作膀胱尿路上皮癌的预后生物标志物。
Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population. We performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated. High EGFR expression was noted in 26.2% (33 cases), 15.1% (19 cases) and 58.7% (74 cases) revealed low and no EGFR expression respectively. Significant association of EGFR expression was noted with tumor grade, lamina propria invasion, deep muscle invasion and recurrence status while no significant association was seen with age, gender and overall survival. Kaplan- Meier curves revealed significant association of EGFR expression with recurrence while no significant association was seen with overall survival. Significant association of EGFR overexpression with tumor grade, muscularis propria invasion and recurrence signifies its prognostic value; therefore EGFR can be used as a prognostic biomarker in Urothelial bladder carcinoma.
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影响因子：
6.7
作者：
GULLICK, WJ
通讯作者：
GULLICK, WJ
影响因子：
3.5
作者：
NGUYEN, PL;SWANSON, PE;NIEHANS, GA
通讯作者：
NIEHANS, GA
影响因子：
6.6
作者：
LUTZEYER, W;RUBBEN, H;DAHM, H
通讯作者：
DAHM, H
影响因子：
6.6
作者：
SKINNER, DG;LIESKOVSKY, G
通讯作者：
LIESKOVSKY, G
DOI：
10.1159/000131829
发表时间：
1983-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
KONDO, I;SHIMIZU, N
通讯作者：
SHIMIZU, N