Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter.
Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter.
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DOI：
10.1289/ehp.6815
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发表时间：
2004-06
影响因子：
10.4
通讯作者：
McLaren CE
中科院分区：
文献类型：
--
作者：
Delfino RJ;Quintana PJ;Floro J;Gastañaga VM;Samimi BS;Kleinman MT;Liu LJ;Bufalino C;Wu CF;McLaren CE
暴露于空气中的颗粒物污染已被证明会加重儿童哮喘，但暴露的来源和时间特征仍在研究中。儿童暴露于PM可能包括与燃烧有关的环境PM和与儿童在各种室内和室外微环境中的活动有关的PM。在19名9-17岁的哮喘儿童中，我们研究了1秒内预测用力呼气量（FEV1）百分比的时间变化与个人连续PM暴露以及在家中和中心部位测量的24小时平均重量PM质量之间的关系。研究对象于1999年秋季或2000年春季在南加州受空气污染影响的地区进行了为期两周的随访。FEV（下标）1（/下标）分别于上午、下午和晚上测量。暴露测量包括使用受试者携带的被动浊度计连续PM；室内、室外和中心站点24小时重力PM2.5（空气动力学直径< 2.5微米的PM）和PM10；中心站点每小时PM10、二氧化氮和臭氧。数据分析采用线性混合模型控制受试者内部自相关、FEV1机动时间和暴露时间。我们发现FEV1与FEV1操作前24小时PM暴露的增加以及多日PM平均值的增加呈负相关。在前24小时测量的给定PM四分位数范围内，预测FEV1百分比（95%置信区间）的缺陷如下：1小时最大个人PM 128微克/立方米，-6.0%(-10.5至-1.4)；30微克/立方米24小时个人平均PM， -5.9% (-10.8 ~ -1.0)；室内家居PM2.5 6.7微克/立方米，-1.6%(-2.8至-0.4)；16微克/立方米室内家庭PM10， -2.1% (-3.7 ~ -0.4)；室内室外PM2.5 7.1微克/立方米，-1.1%(-2.4至0.1)；7.5微克/立方米中心站点PM2.5 -0.7%（-1.9至0.4）。在个人和固定站点PM的多日移动平均中发现了更强的关联。在对室内过敏原过敏的男孩中发现与个人PM有更强的关联。FEV1与NO2呈弱相关，与O3无显著相关性。结果表明，环境背景暴露和不同微环境下的个人暴露对哮喘儿童的呼吸影响是混合的。
Exposure to particulate matter (PM) air pollution has been shown to exacerbate children's asthma, but the exposure sources and temporal characteristics are still under study. Children's exposure to PM is likely to involve both combustion-related ambient PM and PM related to a child's activity in various indoor and outdoor microenvironments. Among 19 children with asthma, 9-17 years of age, we examined the relationship of temporal changes in percent predicted forced expiratory volume in 1 sec (FEV1) to personal continuous PM exposure and to 24-hr average gravimetric PM mass measured at home and central sites. Subjects were followed for 2 weeks during either the fall of 1999 or the spring of 2000, in a southern California region affected by transported air pollution. FEV(subscript)1(/subscript) was measured by subjects in the morning, afternoon, and evening. Exposure measurements included continuous PM using a passive nephelometer carried by subjects; indoor, outdoor home, and central-site 24-hr gravimetric PM2.5 (PM of aerodynamic diameter < 2.5 microm) and PM10; and central-site hourly PM10, nitrogen dioxide, and ozone. Data were analyzed with linear mixed models controlling for within-subject autocorrelation, FEV1 maneuver time, and exposure period. We found inverse associations of FEV1 with increasing PM exposure during the 24 hr before the FEV1 maneuver and with increasing multiday PM averages. Deficits in percent predicted FEV1 (95% confidence interval) for given PM interquartile ranges measured during the preceding 24-hr were as follows: 128 microg/m3 1-hr maximum personal PM, -6.0% (-10.5 to -1.4); 30 microg/m3 24-hr average personal PM, -5.9% (-10.8 to -1.0); 6.7 microg/m3 indoor home PM2.5, -1.6% (-2.8 to -0.4); 16 microg/m3 indoor home PM10, -2.1% (-3.7 to -0.4); 7.1 microg/m3 outdoor home PM2.5, -1.1% (-2.4 to 0.1); and 7.5 microg/m3 central-site PM2.5, -0.7% (-1.9 to 0.4). Stronger associations were found for multiday moving averages of PM for both personal and stationary-site PM. Stronger associations with personal PM were found in boys allergic to indoor allergens. FEV1 was weakly associated with NO2 but not with O3. Results suggest mixed respiratory effects of PM in asthmatic children from both ambient background exposures and personal exposures in various microenvironments.
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影响因子：
5
作者：
Hering, S;Eldering, A;Seinfeld, JH
通讯作者：
Seinfeld, JH
影响因子：
5
作者：
Morawska, L;Thomas, S;Johnson, G
通讯作者：
Johnson, G
影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
影响因子：
10.4
作者：
Delfino RJ;Zeiger RS;Seltzer JM;Street DH;McLaren CE
通讯作者：
McLaren CE
影响因子：
24.3
作者：
Just, J;Ségala, C;Neukirch, F
通讯作者：
Neukirch, F