A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice.
A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice.
复制标题
AA 与火之歌：高血压 SLE 小鼠不同性别依赖性肾脏炎症机制。
DOI：
10.1152/ajpheart.00679.2022
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Banek,ChristopherT
中科院分区：
文献类型：
--
作者：
Gauthier,MadelineM;AlMarabeh,Sara;Banek,ChristopherT
高血压在全世界仍然是一种普遍存在的疾病，是心血管（CVD）和肾脏疾病的主要危险因素。系统性红斑狼疮（SLE）是一种自身免疫性疾病，与一般人群相比，其高血压发病率增加了3-4倍，这增加了他们患CVD和肾脏疾病的风险。由于该患者群体的发病率和死亡率风险增加，因此显然需要进一步研究SLE和相关心血管和肾功能障碍的预测模型、早期诊断和靶向治疗。尽管潜在的病理生理学机制尚不清楚，但通常假设SLE相关的高血压和肾功能不全是由于包括遗传、体液和环境在内的多种因素引起的免疫不耐受的产物。SLE的特征在于自身抗体（AA）的产生、循环促炎细胞因子的增加以及T细胞和B细胞的过度活化，这些都被认为会导致终末器官损伤。31 SLE在女性中更为普遍，估计患病率为男性的4.3-13.6倍32。因此，许多临床前和临床研究都集中在女性身上，使得SLE发病机制中的性别差异仍然是一个研究不足的领域。在最近Chaudhari等人发表在《美国生理学杂志-心脏和循环》第34期的论文中，作者研究了NZBWF 1 SLE小鼠模型中高血压和肾功能不全进展的性别差异。该小组提出了几项重要的发现，开始填补了文献中的这一关键空白，并为未来的研究开辟了几条途径。38
Hypertension remains a pervasive disease throughout the world and is the primary risk factor for 21 cardiovascular (CVD) and renal disease. Patients with systemic lupus erythematosus (SLE), an 22 autoimmune disease, exhibit a 3-4-fold increased incidence of hypertension compared to the general 23 population, which heightens their risk of developing CVD and renal disease 1. Since this patient 24 population is at increased risk of morbidity and mortality, there is a clear need for further research in 25 prediction models, early diagnostics, and targeted therapies for SLE and related cardiovascular and renal 26 dysfunction. Though the underlying pathophysiological mechanisms is still unclear, SLE-associated 27 hypertension and renal dysfunction are generally hypothesized to be a product of immunological 28 intolerance due to a myriad of factors including genetic, humoral, and environmental. SLE is 29 characterized by the production of autoantibodies (AAs), increased circulating proinflammatory 30 cytokines, and overactivation of the T-and B-cells, which are all posited to lead to end organ damage. 31 SLE is more prevalent among females, with estimates ranging from a 4.3-13.6 times higher prevalence 32 compared to males 2. Thus, many preclinical and clinical studies focus on females, leaving sex differences 33 in the pathogenesis of SLE remain an understudied area. In the recent paper from Chaudhari et al. in the 34 American Journal of Physiology–Heart and Circulation 3, the authors investigated the sex differences in 35 hypertension and renal dysfunction progression in the NZBWF1 mouse model of SLE. The group presents 36 several important findings that begin to fill this critical gap in the literature, and which open several 37 avenues for future research. 38
登录
查看更多内容
影响因子：
3.3
作者：
EKER, APM;DEKKER, RH;BERENDS, W
通讯作者：
BERENDS, W
影响因子：
2.9
作者：
LI, YF;HEELIS, PF;SANCAR, A
通讯作者：
SANCAR, A
影响因子：
2.9
作者：
KIM, ST;HEELIS, PF;SANCAR, A
通讯作者：
SANCAR, A
在相位和调制荧光寿命测量中使用等时参考标准。
影响因子：
--
作者：
D. Barrow;Barrty R. Lentz
通讯作者：
Barrty R. Lentz
蓝藻 Anacystis nidulans 光裂合酶基因的克隆和表征。
影响因子：
14.9
作者：
A. Yasui;M. Takao;A. Oikawa;A. Kiener;C. Walsh;A. Eker
通讯作者：
A. Eker