Sleep disturbances are linked to both upper and lower gastrointestinal symptoms in the general population.
Sleep disturbances are linked to both upper and lower gastrointestinal symptoms in the general population.
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DOI：
10.1111/j.1365-2982.2008.01181.x
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发表时间：
2009-02
影响因子：
3.5
通讯作者：
Talley, N. J.
中科院分区：
文献类型：
--
作者：
Cremonini, F.;Camilleri, M.;Zinsmeister, A. R.;Herrick, L. M.;Beebe, T.;Talley, N. J.
在三级转诊患者中，睡眠模式改变、功能性肠病和肠道运动功能改变之间存在关联。体重指数（BMI）也与胃肠道症状（包括腹泻）和睡眠障碍有关。我们的假设是，睡眠障碍与胃肠道症状有关，这不能用BMI来解释。一份48项经验证的问卷邮寄给明尼苏达州奥姆斯特德县的6,939名社区参与者。调查内容包括胃肠道症状、睡眠障碍、日常生活方式和生活质量。采用logistic回归分析，调整年龄、性别、生活方式和心理健康状况，评估睡眠障碍对个体症状的独立贡献。研究了总体睡眠评分与总体症状评分的相关性，并在多元线性回归模型中评估了这两种评分预测SF-12身体和精神功能评分的能力。在3228名受访者中，874人（27%）表示难以入睡。总体睡眠评分与总体GI症状评分显著相关（部分r =0.28，p<0.001）。每晚醒来一次，每月至少4次，与疼痛、恶心、吞咽困难、腹泻、稀便、尿急和肛门堵塞感显著相关。入睡困难与直肠紧迫感显着相关。相关性独立于性别、年龄、生活方式因素和BMI。总体睡眠评分和GI症状评分均为生活质量受损的重要独立预测因子。在社区中，报告睡眠不良与上消化道和下消化道症状有关，但这与BMI无关。
In tertiary referral patients, there is association between altered sleep patterns, functional bowel disorders, and altered gut motor function. Body mass index (BMI) is also associated with GI symptoms including diarrhea, and with sleep disturbances. Our hypothesis is that sleep disturbances are associated with gastrointestinal symptoms, and this is not explained by BMI. A 48-item validated questionnaire was mailed to 6,939 community participants in Olmsted County, MN. The survey included gastrointestinal symptoms, sleep disturbance, daily lifestyle, and quality of life (QOL). Independent contributions of sleep disturbance to individual symptoms were assessed using logistic regression adjusting for age, gender, lifestyle and mental health status. The association of an overall sleep score with an overall symptom score was examined and the ability of both scores to predict SF-12 physical and mental functioning scores assessed in multiple linear regression models. Among 3228 respondents, 874 (27%) reported trouble staying asleep. There was a significant correlation of overall sleep scores with overall GI symptom scores (partial r =0.28, p<0.001). Waking up once nightly at least 4 times a month was significantly associated with pain, nausea, dysphagia, diarrhea, loose stools, urgency and a feeling of anal blockage. Trouble falling asleep was significantly associated with rectal urgency. Associations were independent of gender, age, lifestyle factors and BMI. Overall sleep scores and GI symptom scores were both significant independent predictors of impaired QOL. In the community, reporting poor sleep is associated with upper and lower GI symptoms, but this is independent of BMI.
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影响因子：
24.5
作者：
DAVID, D;MERTZ, H;MAYER, EA
通讯作者：
MAYER, EA
影响因子：
9.6
作者：
Fass, R;Quan, SF;Iber, C
通讯作者：
Iber, C
影响因子：
24.5
作者：
NARDUCCI, F;BASSOTTI, G;MORELLI, A
通讯作者：
MORELLI, A
影响因子：
29.4
作者：
KAHRILAS, PJ;DODDS, WJ;ARNDORFER, RC
通讯作者：
ARNDORFER, RC
DOI：
10.1097/00042737-200209000-00009
发表时间：
2002-09-01
影响因子：
2.1
作者：
Maconi, G;Tosetti, C;Corinaldesi, R
通讯作者：
Corinaldesi, R