Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?
Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?
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DOI：
10.1371/journal.pntd.0001220
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发表时间：
2011-08
影响因子：
3.8
通讯作者：
Bergoin M
中科院分区：
文献类型：
--
作者：
Abd-Alla AM;Parker AG;Vreysen MJ;Bergoin M
许多种类的采采蝇（双翅目：舌蝇科）感染有引起唾液腺肥大（SGH）的病毒，并且具有SGH症状的蝇具有降低的生殖力和生育力。在野生采采蝇种群中，SGH的患病率通常很低（0.2%-5%），但偶尔也观察到较高的患病率（15.2%）。1994-1997年，在安古加岛（桑给巴尔）采用包括昆虫不育技术（SIT）在内的全区域虫害综合管理办法，成功地消灭了一个舌蝇种群，这鼓励了包括埃塞俄比亚在内的几个非洲国家将SIT纳入其国家舌蝇控制方案。2007年在埃塞俄比亚建立了一个大型设施，生产用于SIT的采采蝇。为了支持这一项目，1996年成功建立了一个来自埃塞俄比亚的Glossina pallidipes种群，但后来高达85%的成年苍蝇显示出SGH的症状。结果，殖民地逐渐衰落，并在2002年灭绝。在饲养过程中遇到的困难，G。pallidipes，集中体现为崩溃的G. pallidipes殖民地起源于埃塞俄比亚，促使迫切需要制定管理策略，唾液腺肥大病毒（SGHV），这一物种。作为确定合适的管理策略的第一步，从G.最近对苍白足病毒（GpSGHV）进行了测序，并开始了对病毒传播和病理学的研究。已经提出了不同的方法来防止病毒复制及其在血液喂养期间的水平传播。这些措施包括使用抗病毒药物，如阿昔洛韦和伐昔洛韦添加到血液中用于喂养或使用抗SGHV病毒粒子蛋白的抗体。此外，初步尝试沉默的一个重要的病毒蛋白质的表达，使用RNA干扰将进行讨论。
Many species of tsetse flies (Diptera: Glossinidae) are infected with a virus that causes salivary gland hypertrophy (SGH), and flies with SGH symptoms have a reduced fecundity and fertility. The prevalence of SGH in wild tsetse populations is usually very low (0.2%–5%), but higher prevalence rates (15.2%) have been observed occasionally. The successful eradication of a Glossina austeni population from Unguja Island (Zanzibar) using an area-wide integrated pest management approach with a sterile insect technique (SIT) component (1994–1997) encouraged several African countries, including Ethiopia, to incorporate the SIT in their national tsetse control programs. A large facility to produce tsetse flies for SIT application in Ethiopia was inaugurated in 2007. To support this project, a Glossina pallidipes colony originating from Ethiopia was successfully established in 1996, but later up to 85% of adult flies displayed symptoms of SGH. As a result, the colony declined and became extinct by 2002. The difficulties experienced with the rearing of G. pallidipes, epitomized by the collapse of the G. pallidipes colony originating from Ethiopia, prompted the urgent need to develop management strategies for the salivary gland hypertrophy virus (SGHV) for this species. As a first step to identify suitable management strategies, the virus isolated from G. pallidipes (GpSGHV) was recently sequenced and research was initiated on virus transmission and pathology. Different approaches to prevent virus replication and its horizontal transmission during blood feeding have been proposed. These include the use of antiviral drugs such as acyclovir and valacyclovir added to the blood for feeding or the use of antibodies against SGHV virion proteins. In addition, preliminary attempts to silence the expression of an essential viral protein using RNA interference will be discussed.
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DOI：
10.1038/nrd2485
发表时间：
2007
期刊：
Nature Reviews. Drug Discovery
影响因子：
--
作者：
Clercq ED
通讯作者：
Clercq ED
DOI：
10.1080/00034983.1945.11685209
发表时间：
1945-01-01
影响因子：
--
作者：
BURTT, E
通讯作者：
BURTT, E
DOI：
10.1017/s1742758400010997
发表时间：
1988-01-01
期刊：
INSECT SCIENCE AND ITS APPLICATION
影响因子：
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作者：
KOKWARO, ED;MURITHI, JK
通讯作者：
MURITHI, JK
DOI：
10.1017/s1742758400014909
发表时间：
1993-06-01
期刊：
INSECT SCIENCE AND ITS APPLICATION
影响因子：
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作者：
JURA, WGZO;ZDAREK, J;OTIENO, LH
通讯作者：
OTIENO, LH
影响因子：
5.4
作者：
Fogg, Christiana N.;Arnerico, Jeffrey L.;Moss, Bernard
通讯作者：
Moss, Bernard