The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.
The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.
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DOI：
10.1177/0333102415623070
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Pradhan AA
中科院分区：
文献类型：
--
作者：
Tipton AF;Tarash I;McGuire B;Charles A;Pradhan AA
The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models. We have recently developed a new mouse model of chronic migraine using chronic intermittent nitroglycerin, a known human migraine trigger. The objective of this study was to validate this model by testing known and potential migraine-preventive treatments. Migraine therapies were administered to male and female mice for 11 days. On day 3, mice were tested with nitroglycerin every second day for nine days. Basal and nitroglycerin-evoked mechanical hypersensitivity was evaluated using von Frey filaments. Chronic intermittent nitroglycerin produced acute hyperalgesia with each administration, and progressive and sustained basal hypersensitivity. The established preventive migraine therapy propranolol effectively blocked the development of acute and chronic nitroglycerin-induced hyperalgesia, while valproate had no effect. Potential migraine-preventive therapies were also tested: Amiloride inhibited nitroglycerin-induced acute and chronic hyperalgesia; while memantine was ineffective. We also tested the acute migraine therapy sumatriptan, which did not alter nitroglycerin-induced hyperalgesia, but instead resulted in acute and chronic hyperalgesia similar to that observed following nitroglycerin administration. This study establishes the chronic nitroglycerin model as an additional screening tool to test novel migraine-preventive therapies.
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影响因子：
4.9
作者：
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通讯作者：
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7.4
作者：
Pradhan AA;Smith ML;McGuire B;Tarash I;Evans CJ;Charles A
通讯作者：
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DOI：
10.1124/jpet.106.117101
发表时间：
2007-05-01
影响因子：
3.5
作者：
Peeters, Magali;Gunthorpe, Martin J.;James, Michael F.
通讯作者：
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