Characterization of a novel model of chronic migraine.
Characterization of a novel model of chronic migraine.
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DOI：
10.1016/j.pain.2013.10.004
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发表时间：
2014-02
期刊：
影响因子：
7.4
通讯作者：
Charles A
中科院分区：
文献类型：
--
作者：
Pradhan AA;Smith ML;McGuire B;Tarash I;Evans CJ;Charles A
慢性偏头痛是一种影响全球数亿人的致残疾病。新型偏头痛治疗方法的发展一直很缓慢，部分原因是缺乏预测性动物模型。我们已经开发了一种新的慢性偏头痛模型，涉及使用硝酸甘油，一种已知的人类偏头痛触发器。慢性间歇给药硝酸甘油小鼠每次暴露导致急性机械性痛觉过敏以及进行性和持续性的基础痛觉过敏。这种慢性基底痛觉过敏以剂量依赖性的方式发生，并在停止给药后持续数天。磷酸二酯酶5抑制剂西地那非加重了ntg引起的痛觉过敏，西地那非也是人类偏头痛的诱因，与一氧化氮作为这种痛觉过敏的主要介质一致。急性偏头痛治疗舒马匹坦能显著减轻急性而非慢性基底痛觉过敏，而偏头痛预防治疗托吡酯能显著减轻急性和慢性痛觉过敏。慢性ntg诱导的痛觉过敏是一种小鼠模型，可能有助于研究偏头痛从发作性疾病到慢性疾病进展的机制，并有助于确定和表征新的急性和预防性偏头痛治疗方法。
Chronic migraine is a disabling condition that affects hundreds of millions of individuals worldwide. The development of novel migraine treatments has been slow, in part due to a lack of predicative animal models. We have developed a new model of chronic migraine involving the use of nitroglycerin, a known migraine trigger in humans. Chronic intermittent administration of nitroglycerin to mice resulted in acute mechanical hyperalgesia with each exposure as well as a progressive and sustained basal hyperalgesia. This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days following cessation of NTG administration. NTG-evoked hyperalgesia was exacerbated by the phosphodiesterase 5 inhibitor sildenafil, also a human migraine trigger, consistent with nitric oxide as a primary mediator of this hyperalgesia. The acute but not the chronic basal hyperalgesia was significantly reduced by the acute migraine therapy sumatriptan, whereas both the acute and chronic hyperalgesia was significantly attenuated by the migraine preventive therapy topiramate. Chronic NTG-induced hyperalgesia is a mouse model that may be useful for the study of mechanisms underlying progression of migraine from an episodic to a chronic disorder, and for the identification and characterization of novel acute and preventive migraine therapies.
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影响因子：
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