Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination
Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination
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初级体感皮层的抑制机制介导周围电刺激对触觉空间辨别的影响
DOI：
10.1016/j.neuroscience.2018.05.032
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发表时间：
2018
期刊：
影响因子：
3.3
通讯作者：
Onishi Hideaki
中科院分区：
文献类型：
--
作者：
Saito Kei;Otsuru Naofumi;Inukai Yasuto;Kojima Sho;Miyaguchi Shota;Tsuiki Shota;Sasaki Ryoki;Onishi Hideaki
选择性传入激活可用于改善躯体感觉功能，可能是通过改变皮层抑制回路活动。外周电刺激（PES）被广泛用于诱导选择性传入激活，其效果可能取决于PES强度。因此，我们研究了高强度和低强度PES施加到右手食指上的触觉辨别性能和皮层体感诱发电位双脉冲抑制（SEP-PPD）在25名神经系统健康受试者的影响。在实验1中，光栅定向任务（GOT）之前和之后立即进行本地高强度和低强度PES（都提供了1秒，20赫兹的0.2毫秒的电脉冲，在5秒的间隔）。在实验2中，分别在高强度和低强度PES之前和之后立即评估SEP组分N20/P25_SEP-PPD、N20_SEP-PPD和P25_SEP-PPD的PPD。高强度PES后GOT辨别性能的改善（辨别阈值降低）与基线性能较低（基线辨别阈值较高）相关。受试者被分为低和高（基线）GOT性能组。在低GOT性能组中改善的GOT辨别性能与更大的N20_SEP-PPD降低（更弱的PPD）显著相关。受试者也被分为GOT改善组和GOT降低组。高强度PES使GOT改善组N20_SEP-PPD降低，GOT降低组N20_SEP-PPD升高。此外，在GOT改善组中，GOT辨别阈值的较大降低与N20_SEP-PPD的较大降低显著相关。这些结果表明，高强度PES可以通过调节初级躯体感觉皮层的皮层抑制回路来改善基线功能低下的受试者的躯体感觉知觉。
Selective afferent activation can be used to improve somatosensory function, possibly by altering cortical inhibitory circuit activity. Peripheral electrical stimulation (PES) is widely used to induce selective afferent activation, and its effect may depend on PES intensity. Therefore, we investigated the effects of high- and low-intensity PES applied to the right index finger on tactile discrimination performance and cortical somatosensory-evoked potential paired-pulse depression (SEP-PPD) in 25 neurologically healthy subjects. In Experiment 1, a grating orientation task (GOT) was performed before and immediately after local high- and low-intensity PES (both delivered as 1-s, 20-Hz trains of 0.2-ms electrical pulses at 5-s intervals). In Experiment 2, PPD of SEP components N20/P25_SEP-PPD, N20_SEP-PPD and P25_SEP-PPD, respectively, were assessed before and immediately after high- and low-intensity PES. Improved GOT discrimination performance after high-intensity PES (reduced discrimination threshold) was associated with lower baseline performance (higher baseline discrimination threshold). Subjects were classified into low and high (baseline) GOT performance groups. Improved GOT discrimination performance in the low GOT performance group was significantly associated with a greater N20_SEP-PPD decrease (weaker PPD). Subjects were also classified into GOT improvement and GOT decrement groups. High-intensity PES decreased N20_SEP-PPD in the GOT improvement group but increased N20_SEP-PPD in the GOT decrement group. Furthermore, a greater decrease in GOT discrimination threshold was significantly associated with a greater N20_SEP-PPD decrease in the GOT improvement group. These results suggest that high-intensity PES can improve somatosensory perception in subjects with low baseline function by modulating cortical inhibitory circuits in primary somatosensory cortex.
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影响因子：
9.9
作者：
VANBOVEN, RW;JOHNSON, KO
通讯作者：
JOHNSON, KO
DOI：
10.1016/0168-5597(85)90030-9
发表时间：
1985-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
DESMEDT, JE;BOURGUET, M
通讯作者：
BOURGUET, M
影响因子：
4.7
作者：
Fernandez-del-Olmo, Miguel;Alvarez-Sauco, Maria;Rothwell, John C.
通讯作者：
Rothwell, John C.
影响因子：
5.3
作者：
B. Godde;Beate Stauffenberg;F. Spengler;H. Dinse
通讯作者：
H. Dinse
重复感官刺激后的知觉改善单调取决于刺激强度
影响因子：
7.7
作者：
S. Schlieper;H. Dinse
通讯作者：
H. Dinse