Tactile Coactivation-Induced Changes in Spatial Discrimination Performance
Tactile Coactivation-Induced Changes in Spatial Discrimination Performance
复制标题
触觉共激活引起的空间辨别能力的变化
作者：
B. Godde;Beate Stauffenberg;F. Spengler;H. Dinse
我们在人类心理物理水平上研究了基于共激活的皮层可塑性。对于可塑性的诱导，我们使用了触觉刺激同时配对的协议，以尽可能地遵循Hebbian学习的想法。我们之前报道过，几个小时的触觉协同激活导致成年大鼠的接受野和后肢躯体感觉皮层的皮层图的选择性和可逆重组（Godde et al., 1996）。在本研究中，同时空间两点辨别测试了人类受试者的右手食指指尖作为塑料变化的标志。在2小时的共激活后，我们发现在8小时内可逆转的识别性能显著改善。减少共激活协议的持续时间表明，30分钟不足以驱动塑性变化。连续3天重复应用共激活导致恢复延迟，表明随着时间的推移，改善趋于稳定。知觉变化是高度选择性的，因为没有发现改善的表现转移到未受刺激的手指上。结果表明，在不涉及注意或强化等认知因素的情况下，感觉输入统计（即它们的发生概率和时空关系）在诱导皮质可塑性方面的潜在作用。
We studied coactivation-based cortical plasticity at a psychophysical level in humans. For induction of plasticity, we used a protocol of simultaneous pairing of tactile stimulation to follow as closely as possible the idea of Hebbian learning. We reported previously that a few hours of tactile coactivation resulted in selective and reversible reorganization of receptive fields and cortical maps of the hindpaw representation of the somatosensory cortex of adult rats (Godde et al., 1996). In the present study, simultaneous spatial two-point discrimination was tested on the tip of the right index finger in human subjects as a marker of plastic changes. After 2 hr of coactivation we found a significant improvement in discrimination performance that was reversible within 8 hr. Reduction of the duration of the coactivation protocol revealed that 30 min was not sufficient to drive plastic changes. Repeated application of coactivation over 3 consecutive days resulted in a delayed recovery indicating stabilization of the improvement over time. Perceptual changes were highly selective because no transfer of improved performance to fingers that were not stimulated was found. The results demonstrate the potential role of sensory input statistics (i.e., their probability of occurrence and spatiotemporal relationships) in the induction of cortical plasticity without involving cognitive factors such as attention or reinforcement.
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