Degraded Hyaluronic Acid-Modified Magnetic Nanoparticles

Degraded Hyaluronic Acid-Modified Magnetic Nanoparticles
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降解透明质酸修饰磁性纳米粒子

DOI:
10.1155/2020/1084890
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发表时间:
2020-02
影响因子:
--
通讯作者:
韩栋
韩栋
中科院分区:
材料科学4区
文献类型:
--
作者:
聂婉;张宝林;严宪佳;苏礼超;汪晟;韩贵华;韩栋

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Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with hyaluronic acid (HA) functional groups have potential applications as cell targeting materials. However, SPIONs incubated with high-molecular weight HA can result in severe agglomeration. In this work, we found that when modified with degraded HA (hyaluronan oligosaccharides (oHAs)), the nanoparticles were uniformly dispersed with small hydrodynamic sizes, and the oHA-modified SPIONs exerted minimal cytotoxicity. With the same functional groups as HA, the oHA-modified SPIONs may have various biomedical applications.
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