The Effects of Serotonin in Immune Cells.
The Effects of Serotonin in Immune Cells.
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DOI：
10.3389/fcvm.2017.00048
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发表时间：
2017
影响因子：
3.6
通讯作者：
Duerschmied D
中科院分区：
文献类型：
--
作者：
Herr N;Bode C;Duerschmied D
血清素[5-羟色胺（5-HT）]作为一种外周激素在许多器官中发挥重要作用。人体的大部分血清素在血液中循环，由血小板运输，并在激活时释放。5-羟色胺的功能由7种已知的哺乳动物5-羟色胺受体亚型（15种已知亚型）的成员、5-羟色胺转运蛋白（SERT）以及5-羟色胺与不同效应蛋白的共价结合介导。几乎所有的免疫细胞都表达至少一种血清素成分。近年来，许多免疫调节功能已被归因于血清素。例如，在单核细胞/巨噬细胞中，5-羟色胺调节细胞因子分泌。5-羟色胺还可以通过激活5-羟色胺受体来抑制肿瘤坏死因子-α和白细胞介素-1 β的释放。此外，中性粒细胞募集和T细胞活化都可以由血清素介导。这些只是我们在这里回顾的5-羟色胺的免疫调节作用中的一小部分。
Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body’s serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation. The functions of serotonin are mediated by members of the 7 known mammalian serotonin receptor subtype classes (15 known subtypes), the serotonin transporter (SERT), and by covalent binding of serotonin to different effector proteins. Almost all immune cells express at least one serotonin component. In recent years, a number of immunoregulatory functions have been ascribed to serotonin. In monocytes/macrophages, for example, serotonin modulates cytokine secretion. Serotonin can also suppress the release of tumor necrosis factor-α and interleukin-1β by activating serotonin receptors. Furthermore, neutrophil recruitment and T-cell activation can both be mediated by serotonin. These are only a few of the known immunomodulatory roles of serotonin that we will review here.
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影响因子：
4.4
作者：
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通讯作者：
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