Association of personality traits with physical function, cognition, and mood in multiple sclerosis.
Association of personality traits with physical function, cognition, and mood in multiple sclerosis.
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DOI：
10.1016/j.msard.2022.103648
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发表时间：
2022-03
影响因子：
4
通讯作者：
Leavitt VM
中科院分区：
文献类型：
--
作者：
Kever A;Walker ELS;Riley CS;Heyman RA;Xia Z;Leavitt VM
越来越多的文献支持人格影响健康结果的假设。很少有研究研究多发性硬化症(PWMS)患者的人格特征和主要临床表现之间的联系。在这项横断面研究中，为了调查人格特征是否与MS患者的身体功能、认知和抑郁有关，我们分析了来自两个队列(UPMC，n=365和CUIMC，n=129)的数据。参与者完成了一份人格问卷(评估神经质、外向、开放性、宜人性和尽职尽责)，并完成了测量身体功能、认知和抑郁的有效调查。逐步线性回归被用来评估人格特征和结果测量之间的关联。在队列中，高外向与更好的身体功能相关，而更高的神经质与更严重的抑郁相关。在第一个队列中，较高的外向与更好的认知相关，而在第二个队列中，较高的神经质与更大的记忆损伤风险相关。这种关系与年龄和病程无关。研究结果表明，在多发性硬化症患者报告的临床结果中，外向的潜在保护作用和神经质的有害作用。对人格和健康结果之间相互作用的更多了解可能会为PWMS中身体衰退、认知障碍和抑郁的风险模型提供信息。
Growing literature supports the hypothesis that personality influences health outcomes. Few studies have examined the association between personality traits and key clinical manifestations in persons with multiple sclerosis (pwMS). To investigate whether personality traits are associated with physical function, cognition, and depression in persons with MS. In this cross-sectional study, we analyzed data from two cohorts (UPMC, n=365 and CUIMC, n=129). Participants completed a personality scale (assessing neuroticism, extraversion, openness, agreeableness, and conscientiousness) and validated surveys measuring physical function, cognition, and depression. Stepwise linear regressions were used to evaluate associations between personality traits and outcome measures. Consistently across cohorts, higher extraversion was associated with better physical function, whereas higher neuroticism was associated with worse depression. In the first cohort, higher extraversion was associated with better cognition, while higher neuroticism was associated with greater risk for memory impairment in the second cohort. Relationships were independent of age and disease duration. Findings suggest a potentially protective role of extraversion, and a harmful role of neuroticism, in MS-specific patient-reported clinical outcomes. Increased understanding of the interplay between personality and health outcomes may inform risk models for physical decline, cognitive impairment, and depression in pwMS.
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影响因子：
3.5
作者：
Rogalski E;Gefen T;Mao Q;Connelly M;Weintraub S;Geula C;Bigio EH;Mesulam MM
通讯作者：
Mesulam MM
影响因子：
2.2
作者：
Royle, Jane;Lincoln, Nadina B.
通讯作者：
Lincoln, Nadina B.
影响因子：
1.4
作者：
Akbar, Nadine;Honarmand, Kimia;Feinstein, Anthony
通讯作者：
Feinstein, Anthony
多发性硬化症患者的人格特征及其与临床特征的关系
影响因子：
1.9
作者：
Gazioglu, Sibel;Cakmak, Vildan Altunayoglu;Boz, Cavit
通讯作者：
Boz, Cavit
影响因子：
5.8
作者：
Kever, Anne;Buyukturkoglu, Korhan;Leavitt, Victoria M.
通讯作者：
Leavitt, Victoria M.