Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases.
Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases.
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DOI：
10.1002/hipo.22828
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发表时间：
2019-05
期刊：
影响因子：
3.5
通讯作者：
Mesulam MM
中科院分区：
文献类型：
--
作者：
Rogalski E;Gefen T;Mao Q;Connelly M;Weintraub S;Geula C;Bigio EH;Mesulam MM
平均而言，50-60奥尔兹人群的记忆能力明显高于80奥尔兹人群。我们将超级老人定义为80岁或以上的人，他们的情景记忆能力至少与50多岁和60多岁的普通人一样好。因此，超级老年人的记忆能力比年龄大的人更上级。以前的研究表明，超级老人比同龄的“认知平均”个体有更大的皮质体积和更大的抵抗力，以应对与年龄相关的皮质萎缩。在这里，我们报告的认知，个性和神经病理学特征的前10个尸检病例在西北超级老龄化计划。在随访期间，7名超级老年人的情景记忆表现保持在50-65岁正常人的平均范围内或以上，所有10名超级老年人的情景记忆得分都保持在他们自己年龄的正常范围内。在NEO-PI-R人格测量中，外向性得分往往很高。10例尸检标本显示出阿尔茨海默病病理学范围内的不同发现。Braak Ⅱ-Ⅲ期海马和内嗅皮质神经元变性较多。然而，即使是这些边缘系统区域也包含许多健康的神经元，新皮层通常没有神经元变性。相比之下，至少有5例病例的新皮质区含有中到高密度的神经炎斑块。这些发现需要放在背景下，通过将它们与同龄认知平均个体的神经病理学进行比较。未来对超级老年人的研究可能会深入了解那些阻止大脑中出现退化变化的因素，或者使认知功能更能抵抗其后果的因素。
On average, memory capacity is significantly higher in populations of 50-60 year olds than in populations of 80 year olds. We define SuperAgers as individuals 80 or older whose episodic memory capacity is at least as good as that of cognitively average individuals in their 50s and 60s. SuperAgers therefore have memory capacity that is superior for age. Previous work showed that SuperAgers have greater cortical volumes and greater resistance to age-related cortical atrophy than ‘cognitively average’ individuals of the same age. Here we report on the cognitive, personality, and neuropathologic characteristics of the first 10 autopsy cases in the Northwestern SuperAging Program. During the follow-up period, seven SuperAgers maintained episodic memory performance within or above the average range for 50–65 year-old norms and all 10 SuperAgers maintained episodic memory scores within normal limits for their own age. Extraversion scores tended to be high on the NEO-PI-R measure of personality. The 10 autopsy specimens showed variable findings within the spectrum of Alzheimer pathology. The hippocampus and entorhinal cortex contained neurofibrillary degeneration mostly in the Braak II-III stages. However, even these limbic areas contained many healthy appearing neurons and the neocortex was generally free of neurofibrillary degeneration. In contrast, neocortical areas in at least 5 of the cases contained moderate to high densities of neuritic plaques. These findings need to be placed in context by comparing them to the neuropathology of cognitively average individuals of the same age. Future research on SuperAgers is likely to offer insights into factors that either prevent the emergence of involutional changes in the brain or that makes cognitive function more resistant to their consequences.
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影响因子：
12.7
作者：
Kovacs GG;Ferrer I;Grinberg LT;Alafuzoff I;Attems J;Budka H;Cairns NJ;Crary JF;Duyckaerts C;Ghetti B;Halliday GM;Ironside JW;Love S;Mackenzie IR;Munoz DG;Murray ME;Nelson PT;Takahashi H;Trojanowski JQ;Ansorge O;Arzberger T;Baborie A;Beach TG;Bieniek KF;Bigio EH;Bodi I;Dugger BN;Feany M;Gelpi E;Gentleman SM;Giaccone G;Hatanpaa KJ;Heale R;Hof PR;Hofer M;Hortobágyi T;Jellinger K;Jicha GA;Ince P;Kofler J;Kövari E;Kril JJ;Mann DM;Matej R;McKee AC;McLean C;Milenkovic I;Montine TJ;Murayama S;Lee EB;Rahimi J;Rodriguez RD;Rozemüller A;Schneider JA;Schultz C;Seeley W;Seilhean D;Smith C;Tagliavini F;Takao M;Thal DR;Toledo JB;Tolnay M;Troncoso JC;Vinters HV;Weis S;Wharton SB;White CL 3rd;Wisniewski T;Woulfe JM;Yamada M;Dickson DW
通讯作者：
Dickson DW
影响因子：
1.9
作者：
De Frias, Cindy M.;Nilsson, Lars-Goran;Herlitz, Agneta
通讯作者：
Herlitz, Agneta
DOI：
10.1097/01.jgp.0000192501.03069.bc
发表时间：
2006-01-01
影响因子：
7.2
作者：
Depp, CA;Jeste, DV
通讯作者：
Jeste, DV
影响因子：
3.7
作者：
Cook Maher A;Kielb S;Loyer E;Connelley M;Rademaker A;Mesulam MM;Weintraub S;McAdams D;Logan R;Rogalski E
通讯作者：
Rogalski E
影响因子：
3.7
作者：
McCarrey, Anna C.;An, Yang;Resnick, Susan M.
通讯作者：
Resnick, Susan M.