High prevalence of Schistosoma japonicum by perfusion in naturally exposed water buffalo in a region of the Philippines endemic for human schistosomiasis.
High prevalence of Schistosoma japonicum by perfusion in naturally exposed water buffalo in a region of the Philippines endemic for human schistosomiasis.
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在菲律宾一个人类血吸虫病流行地区，通过灌注自然暴露的布法罗中日本血吸虫的高流行率
DOI：
10.1371/journal.pntd.0009796
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发表时间：
2021-09
影响因子：
3.8
通讯作者：
Wu HW
中科院分区：
文献类型：
--
作者：
Jiz M;Mingala C;Fu ZQ;Adriatico M;Lu K;Jarilla B;Sagliba M;Moreno A;Park S;Lin JJ;Olveda R;Kurtis JD;Wu HW
在过去的十年中，生态调查强调老鼠和狗是菲律宾最重要的日本血吸虫（S.j）动物宿主。然而，最近的研究表明，在菲律宾 Sj 流行地区，使用 qPCR 技术发现水牛血吸虫病患病率为 51-91%。为了解决关于水牛（一种最重要的役用动物）水吸虫病流行的调查报告不一致的问题，我们向菲律宾莱特岛贾罗市马卡尼普引入了42头血吸虫阴性水牛，这是一个自给稻作村，过去20年来一直是我们小组日本血吸虫病研究的重点。我们对在自然暴露和台风海燕中存活了 10 个月的剩余 34 头水牛进行了灌注。 33 头水牛的肠系膜静脉中至少有 1 对蠕虫呈阳性。感染率为 97%，蠕虫负担为 94 条（95% 置信区间，49-138 条蠕虫）蠕虫。据我们所知，这是第一份关于菲律宾自然感染水牛体内日本血吸虫蠕虫负担的报告。令人震惊的是，在这个人类血吸虫病流行区，暴露时间不到一年，34 头水牛中只有 1 头没有受到感染。迫切需要关注一种经济有效的技术来监测动物和人类的 Sj 感染。同时，应考虑实施干预措施，包括水牛治疗和疫苗接种。日本血吸虫病是一种人畜共患病，水牛（水牛）是主要的非人类宿主。在菲律宾，之前基于对水牛粪便进行常规粪便检查的报告得出的结论是，日本血吸虫感染的流行率较低。现在，我们通过水牛灌注来报告血吸虫负担数据，这些水牛以前未受感染，随后由于迁移到流行严重的村庄而暴露于 Sj。对菲律宾莱特岛 Macanip 的 34 头水牛进行灌注后发现，在暴露 10 个月后，34 头水牛中有 33 头（97%）的肠系膜静脉中至少有一对日本血吸虫。迄今为止，尚未发表来自菲律宾自然暴露的水牛的直接蠕虫恢复报告。我们的数据表明，考虑到水牛作为重要的干旱动物及其在人类血吸虫病传播中的作用，需要紧急关注菲律宾 Sj 感染控制的综合测量。
In the past decade, ecological surveys emphasized rats and dogs as the most significant animal reservoirs for Schistosoma japonicum (S.j) in the Philippines. However, recent studies demonstrated 51–91% prevalence of schistosomiasis among water buffalo using qPCR in the Sj endemic regions in the Philippines. In order to resolve the inconsistency of reported surveys regarding Sj endemicity among carabao, a domestic water buffalo that is the most important draught animal, we introduced 42 schistosome negative water buffalo to Macanip, Jaro municipality, Leyte, the Philippines, a subsistence rice-farming village that has been the focus of schistosomiasis japonica studies of our group for the past 20 years. We conducted perfusion to the remaining 34 buffalo that survived 10 months of nature exposure and Typhoon Haiyan. Thirty-three water buffalo were found to be positive with at least 1 pair of worms from the mesenteric vein. The infection rate is 97%, with the worm burden of 94 (95% confidence interval, 49–138 worms) worms. To our knowledge, this is the first report about S. japonicum worm burden in naturally infected water buffalo in the Philippines. The fact that with less than one-year of exposure, in this human schistosomiasis endemic area, only 1 out of 34 water buffalo was uninfected is striking. Urgent attention is needed for a cost-effective technique for monitoring Sj infection in animals and humans. Meanwhile, intervention implementation, including water buffalo treatment and vaccination, should be taken into consideration. Schistosomiasis japonica is a zoonosis, with water buffalo (carabao) constituting a major non-human reservoir. In the Philippines, previous reports based on conventional coprological examination of carabao feces have concluded that the prevalence of S. japonicum infection is low. We now report schistosome worm burden data by perfusion from water buffalo that were previously uninfected and subsequently exposed to Sj by moving to highly endemic villages. Perfusion of 34 water buffalo in Macanip, Leyte, Philippines revealed that 33 out of the 34 animals (97%) had at least one pair of S. japonicum worms in the mesenteric veins after 10 months of exposure. To date, no direct worm recovery report from naturally exposed water buffalo in the Philippines has been published. Our data suggested that urgent attention is needed to qualify the integrated measurements for Sj infection control in the Philippines, considering water buffalo as an important drought animal and its role in human schistosomiasis transmission.
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影响因子：
11.1
作者：
Angeles JM;Leonardo LR;Goto Y;Kirinoki M;Villacorte EA;Hakimi H;Moendeg KJ;Lee S;Rivera PT;Inoue N;Chigusa Y;Kawazu S
通讯作者：
Kawazu S
影响因子：
3.8
作者：
Lier T;Simonsen GS;Wang T;Lu D;Haukland HH;Vennervald BJ;Johansen MV
通讯作者：
Johansen MV
影响因子：
168.9
作者：
通讯作者：
--
影响因子：
2.6
作者：
Kenworthy, JD;Ye, P;Coles, GC
通讯作者：
Coles, GC
影响因子：
1.7
作者：
Mingala, Claro N.;Gundran, Romeo S.
通讯作者：
Gundran, Romeo S.