TRP Channels in Sensory Transduction
TRP Channels in Sensory Transduction
复制标题
感觉传导中的 TRP 通道
DOI：
10.1007/978-3-319-18705-1_8
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Tan C
中科院分区：
文献类型：
--
作者：
Tan C
动物必须感知外部环境的温度，以找到适合不同活动的环境温度，如狩猎或睡眠，并避免短暂暴露于极端温度。TRP通道家族的一些成员被热刺激激活，因此被命名为thermoTRP;热敏离子通道也存在于钾和氯离子通道家族中。当thermoTRP通道在感觉神经元中表达时，响应于热的通道开放导致去极化和动作电位的产生。它仍然是一个悬而未决的问题，哪些通道是重要的感觉在外部环境中的热刺激，和通道参与的感觉内部身体温度的体温调节的目的是更少的了解。在本章中，我们回顾了热敏离子通道的特性及其在温度感觉和体温调节中的作用，重点是TRP通道。
Animals must sense temperature in the external environment in order to find ambient temperatures appropriate for different activities, such as hunting or sleeping, and to avoid even brief exposure to damaging extremes of temperature. They must also sense their internal bodily temperature in order to regulate it. Some members of the TRP channel family are activated by thermal stimuli, and are consequently named the thermoTRPs; thermally sensitive ion channels are also found in the potassium and chloride channel families. When thermoTRP channels are expressed in a sensory neuron, channel opening in response to heat leads to depolarization and generation of action potentials. It is still an open question which channels are important for sensation of thermal stimuli in the external environment, and channels involved in the sensation of internal bodily temperature for the purposes of thermoregulation are even less understood. In this chapter we review the properties of thermosensitive ion channels and their roles in thermosensation and thermoregulation, with an emphasis on TRP channels.
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影响因子：
4.8
作者：
Erler, Isabell;Al-Ansary, Dalia M. M.;Niemeyer, Barbara A.
通讯作者：
Niemeyer, Barbara A.
影响因子：
5.3
作者：
Madrid, Rodolfo;de la Pena, Elvira;Viana, Felix
通讯作者：
Viana, Felix
影响因子：
3.4
作者：
COLE, KS;MOORE, JW
通讯作者：
MOORE, JW
DOI：
10.1073/pnas.0703420104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Brauchi, Sebastian;Orta, Gerardo;Latorre, Ramon
通讯作者：
Latorre, Ramon
影响因子：
--
作者：
Gaudet, Rachelle
通讯作者：
Gaudet, Rachelle