The Association between Suicide Attempts and Toxoplasma gondii Infection.
The Association between Suicide Attempts and Toxoplasma gondii Infection.
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DOI：
10.9758/cpn.2018.16.1.95
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发表时间：
2018-02-28
期刊：
影响因子：
--
通讯作者：
Lee YJ
中科院分区：
文献类型：
--
作者：
Bak J;Shim SH;Kwon YJ;Lee HY;Kim JS;Yoon H;Lee YJ
弓形虫慢性潜伏感染是常见的，大多数宿主症状轻微，甚至无症状。然而，T.弓形虫会影响人的行为，也可能导致人自杀。本文旨在探讨自杀未遂与T。韩国的弓形虫感染采用酶联免疫法和荧光抗体技术对155例有自杀企图的精神病患者和135例健康对照者进行了T。弓形虫血清阳性和抗体滴度。采用汉密尔顿抑郁量表（HAMD）、哥伦比亚自杀严重程度评定量表（C-SSRS）、状态-特质焦虑量表（STAI）和韩国-巴拉特冲动量表（BIS）对自杀未遂者进行问卷调查。在155名自杀者中的21名和135名对照者中的8名中发现了免疫球蛋白G抗体（p = 0.011）。弓形虫血清阳性自杀者在抑郁情绪和内疚感分量表上的HAMD评分和总分均高于血清阴性自杀者。t.弓形虫血清阳性状态与严重程度和致死性分量表中较高的C-SSRS相关。t.在自杀组中，弓形虫IgG血清阳性与较高的STAI-X1评分显著相关。自杀者T.比健康对照组更高。在自杀者中，T。弓形虫抗体阳性组与阴性组在自杀方面存在差异。这些结果表明T.自杀行为中的弓形虫感染与精神问题
Chronic ‘latent’ infection by Toxoplasma gondii is common and most of the hosts have minimal symptoms or they are even asymptomatic. However, there are possible mechanisms by which T. gondii may affect human behavior and it may also cause humans to attempt suicide. This article aimed to investigate the potential pathophysiological relationship between suicide attempts and T. gondii infection in Korea. One hundred fifty-five psychiatric patients with a history of suicide attempt and 135 healthy control individuals were examined with enzyme-linked immunoassays and fluorescent antibody technique for T. gondii seropositivity and antibody titers. The group of suicide attempters was interviewed regarding the history of suicide attempt during lifetime and evaluated using 17-item Korean version of Hamilton Depression Scale (HAMD), Columbia Suicide Severity Rating Scale (C-SSRS), State-Trait Anxiety Inventory (STAI) and Korean-Barratt Impulsiveness Scale (BIS). Immunoglobulin G antibodies were found in 21 of the 155 suicide attempters and in 8 of the 135 controls (p=0.011). The Toxoplasma-seropositive suicide attempters had a higher HAMD score on the depressed mood and feeling of guilt subscales and a higher total score than the seronegative suicide attempters. T. gondii seropositive status was associated with higher C-SSRS in the severity and lethality subscales. T. gondii IgG seropositivity was significantly associated with higher STAI-X1 scores in the suicide attempters group. Suicide attempters showed higher seroprevalence of T. gondii than healthy controls. Among the suicide attempters, the T. gondii seropositive and seronegative groups showed several differences in the aspects of suicide. These results suggested a significant association between T. gondii infection and psychiatric problems in suicidality.
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