Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018.
Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018.
复制标题
2001年至2018年之间，中非共和国的人类猴痘的基因组史。
DOI：
10.1038/s41598-021-92315-8
复制
发表时间：
2021-06-22
影响因子：
4.6
通讯作者：
Nakoune E
中科院分区：
文献类型：
--
作者：
Berthet N;Descorps-Declère S;Besombes C;Curaudeau M;Nkili Meyong AA;Selekon B;Labouba I;Gonofio EC;Ouilibona RS;Simo Tchetgna HD;Feher M;Fontanet A;Kazanji M;Manuguerra JC;Hassanin A;Gessain A;Nakoune E
猴痘是一种新发传染病，其临床表现与天花相似。在过去的二十年中，中部非洲的病例频率有所增加，在刚果民主共和国（DRC）和中非共和国（CAR）发现了许多猴痘病毒（MPXV）分离株。迄今为止，尚未公布 CAR 中发现的人类病例的完整 MPXV 病毒基因组。本研究的目的是对 2001 年至 2018 年 CAR 流行期间收集的 10 个 MPXV 分离株的全基因组进行测序，以确定它们在先前描述的中非和西非 MPXV 谱系之间的系统发育关系。我们的系统发育结果表明，10 个 CAR 分离株属于与刚果民主共和国发现的密切相关的三个谱系。系统发育模式表明它们都出现在刚果盆地的雨林区。由于中非共和国的大多数人类指示病例发生在西部和东部雨林的北部边缘，因此最可能的假设是生活在雨林中的野生动物传播。此外，分子测年估计表明，严重的政治不稳定时期导致国内人口流动，通常也与贫困加剧有关，这可能导致与宿主野生动物的更频繁接触。中非共和国的社会经济形势、武装冲突和生态扰乱可能会促使人们越来越多地与野生动物互动，从而增加人畜共患病蔓延的风险。
Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa has seen an increase in the frequency of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Republic of Congo (DRC) and the Central African Republic (CAR). To date, no complete MPXV viral genome has been published from the human cases identified in the CAR. The objective of this study was to sequence the full genome of 10 MPXV isolates collected during the CAR epidemics between 2001 and 2018 in order to determine their phylogenetic relationships among MPXV lineages previously described in Central Africa and West Africa. Our phylogenetic results indicate that the 10 CAR isolates belong to three lineages closely related to those found in DRC. The phylogenetic pattern shows that all of them emerged in the rainforest block of the Congo Basin. Since most human index cases in CAR occurred at the northern edge of western and eastern rainforests, transmissions from wild animals living in the rainforest is the most probable hypothesis. In addition, molecular dating estimates suggest that periods of intense political instability resulting in population movements within the country often associated also with increased poverty may have led to more frequent contact with host wild animals. The CAR socio-economic situation, armed conflicts and ecological disturbances will likely incite populations to interact more and more with wild animals and thus increase the risk of zoonotic spillover.
登录
查看更多内容
影响因子：
14.9
作者：
Abascal F;Zardoya R;Telford MJ
通讯作者：
Telford MJ
影响因子：
2.5
作者：
Doshi, Reena H.;Alfonso, Vivian H.;Rimoin, Anne W.
通讯作者：
Rimoin, Anne W.
影响因子：
64.5
作者：
ALCAMI, A;SMITH, GL
通讯作者：
SMITH, GL
影响因子：
3.1
作者：
Aitichou, Mohamed;Saleh, Sharron;Ibrahim, Sofi
通讯作者：
Ibrahim, Sofi
影响因子：
3.1
作者：
Meyer, H;Ropp, SL;Esposito, JJ
通讯作者：
Esposito, JJ