Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland.
Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland.
复制标题
芬兰非胰岛素依赖型糖尿病和非糖尿病受试者中肺炎衣原体与急性冠心病事件的关联。
DOI：
10.1093/oxfordjournals.eurheartj.a014934
复制
发表时间：
1996
影响因子：
39.3
通讯作者：
Markku Laakso
中科院分区：
文献类型：
--
作者：
H. Miettinen;S. Lehto;Pekka Saikku;S. M. Haffner;Tapani Rönnemaa;K. Pyörälä;Markku Laakso
客观的
OBJECTIVE
It has been suggested that Chlamydia pneumoniae, a Gram-negative intracellular bacterium, is a risk factor for both myocardial infarction and chronic coronary heart disease. Previous studies have been done predominantly in non-diabetic subjects and thus the effect of diabetes on the association between C. pneumoniae antibodies and coronary heart disease has not been analysed. The aim of our study was to investigate the association between prior chlamydial infection and the risk of serious coronary heart disease events (myocardial infarction or coronary death) in a 7-year prospective study of cohorts of diabetic and non-diabetic subjects in two areas of Finland.
RESULTS
It was found that the prevalence of elevated chlamydial antibodies at baseline was higher in nondiabetic subjects who had serious coronary heart disease events during the follow-up than in subjects without coronary heart disease events (32 vs 15%, relative risk 2.56, P = 0.013) in East Finland. In non-diabetic subjects living in West Finland we did not find this association. The association between the C. pneumoniae antibodies and coronary heart disease events did not markedly change after controlling for other risk factors for coronary heart disease (OR 2.44, P = 0.055) in non-diabetic subjects living in eastern Finland. In diabetic patients we did not find any association between chlamydial antibodies and coronary heart disease events.
CONCLUSION
We found an association between C. pneumoniae antibodies and coronary heart disease events in non-diabetics living in eastern Finland. This association remained strong even after controlling for the other risk factors for coronary heart disease. In diabetic patients with high risk for coronary heart disease, C. pneumoniae was not a risk factor for coronary heart disease.
DOI：
10.1161/01.atv.13.10.1501
发表时间：
1993-10-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
KUO, CC;GOWN, AM;GRAYSTON, JT
通讯作者：
GRAYSTON, JT
冠状动脉脂肪条纹和粥样斑块中肺炎衣原体的检测。
DOI：
--
发表时间：
1992
期刊：
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
影响因子：
--
作者：
Shor,A;Kuo,CC;Patton,DL
通讯作者：
Patton,DL
肺炎衣原体菌株 TWAR 抗体和血管造影显示冠状动脉疾病。
DOI：
10.1161/01.atv.11.3.547
发表时间：
1991
期刊：
Arteriosclerosis and thrombosis : a journal of vascular biology
影响因子：
--
作者：
Thom,DH;Wang,SP;Grayston,JT;Siscovick,DS;Stewart,DK;Kronmal,RA;Weiss,NS
通讯作者：
Weiss,NS