An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.
An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.
复制标题
与海马突触长期增强相关的空间信息获取和遗忘率的年龄比较。
DOI：
10.1037//0735-7044.99.6.1040
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
McNaughton,BL
中科院分区：
文献类型：
--
作者：
Barnes,CA;McNaughton,BL
年龄差异的收购率和遗忘的空间记忆问题进行了比较，相应的差异的增长率和衰减的长期突触增强（LTE）的海马突触，诱导高频刺激的穿通路径纤维。老年动物接近他们的最终渐近性能水平比年轻的动物更慢，并表现出更快的速度忘记的问题。同样，LTE在老年动物中达到最大值的速度更慢，衰减更快。虽然行为获得和遗忘的绝对速率与LTE的相应增加和衰减速率不同，但年龄组之间的相对差异相当相似。这对于遗忘与LTE衰减的比较尤其如此。这些数据的关系，LTE的基础空间学习和记忆的假设进行了讨论。
Age differences in the rates of acquisition and forgetting of a spatial memory problem were compared with corresponding differences in the rates of increase and decay of long-term synaptic enhancement (LTE) of hippocampal synapses, induced by high-frequency stimulation of perforant path fibers. Old animals approached their final asymptotic performance levels more slowly than did the young animals and exhibited faster rates of forgetting of the problem. Similarly, LTE reached its maximum more slowly in the old animals and decayed more quickly. Although the absolute rates of behavioral acquisition and forgetting were different from the corresponding rates of increase and decay of LTE, the relative differences between age groups were rather similar. This was particularly true for the comparison of forgetting with LTE decay. The relation of these data to the hypothesis that LTE underlies spatial learning and memory is discussed.
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期刊：
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