Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression.
Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression.
复制标题
主观和客观睡眠质量调节焦虑和抑郁情绪调节脑功能。
DOI：
10.1002/da.22622
复制
发表时间：
2017-07
影响因子：
7.4
通讯作者：
Phan KL
中科院分区：
文献类型：
--
作者：
Klumpp H;Roberts J;Kapella MC;Kennedy AE;Kumar A;Phan KL
情绪调节和睡眠障碍在焦虑和情绪障碍中是共同的。睡眠不佳已被证明会损害认知过程，这可能会破坏认知调节功能。然而，睡眠质量是否会影响临床焦虑和抑郁的调节机制仍然未知。在功能磁共振成像中，78名社交焦虑症、广泛性焦虑症和/或重度抑郁症患者完成了一项有效的情绪调节任务，其中包括重新评价（即，减少负面影响）。睡眠质量评估与匹兹堡睡眠质量指数（PSQI）和体动仪，分别代表主观和客观的睡眠措施。回归分析与PSQI和体动记录睡眠效率，持续时间和觉醒后睡眠开始变量。PSQI和体动仪测量表明，大多数患者经历了有问题的睡眠，然而，主观和客观的睡眠测量是不相关的。控制诊断的全脑体素回归分析显示，自我报告的睡眠更差，与背侧前扣带皮层（DACC）的重新评估相关激活较少相对应。对体动记录数据进行的相同分析显示，睡眠效率较低与DACC激活呈正相关。事后逐步回归分析显示，这些睡眠指标预测DACC活动，而焦虑和抑郁症状没有。自我感知和客观睡眠质量的个体差异差异调制DACC，这与认知重新评价有关。研究结果表明，情绪调节的神经相关性跟踪睡眠体验的不同方面。结果还表明，睡眠障碍可能在焦虑和抑郁症中观察到的情绪失调中发挥作用。
Disturbances in emotion regulation and sleep are shared across anxiety and mood disorders. Poor sleep has been shown to impair cognitive processes which may undermine cognitive regulatory function. However, it remains unknown if sleep quality impacts regulatory mechanisms in clinical anxiety and depression. During fMRI, 78 patients with social anxiety disorder, generalized anxiety disorder, and/or major depressive disorder completed a validated emotion regulation task, which involved reappraisal (i.e., decrease negative affect) as compared to viewing aversive images. Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and actigraphy, representing subjective and objective measures of sleep, respectively. Regression analysis was conducted with the PSQI and actigraphy sleep efficiency, duration, and wake-after sleep onset variables. PSQI and actigraphy measures indicated that the majority of patients experienced problematic sleep, however, subjective and objective sleep measures were uncorrelated. Whole-brain voxel-wise regression analysis, controlling for diagnosis, revealed worse self-reported sleep corresponded with less reappraise-related activation in the dorsal anterior cingulate cortex (DACC). The same analysis performed with actigraphy data showed less sleep efficiency positively corresponded with DACC activation. Post-hoc stepwise regression analysis showed these sleep measures predicted DACC activity whereas anxiety and depression symptoms did not. Individual differences in self-perceived and objective sleep quality differentially modulated the DACC, which is implicated in cognitive reappraisal. Findings suggest neural correlates of emotion regulation tracks different aspects of the sleep experience. Results also indicate sleep disturbance may play a role in the emotion dysregulation observed in anxiety and depressive disorders.
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