Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder.
Functional neuroimaging of reward circuitry responsivity to monetary gains and losses in posttraumatic stress disorder.
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DOI：
10.1016/j.biopsych.2009.06.006
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发表时间：
2009-12-15
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
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作者：
临床印象和临床前工作表明，创伤后应激障碍（PTSD）可能与奖励处理功能障碍有关。为了解决这个问题，我们在功能性磁共振成像（fMRI）过程中对慢性PTSD患者和精神健康个体进行了一项有效的被动观察金钱奖励任务。该方案评估了在不同的受控预期条件下预期或伴随货币收益和损失的fMRI信号变化。“期望阶段”需要呈现有希望、无希望或中间的旋转轮，而“结果阶段”由箭头落在旋转轮的三个扇区之一上来定义，从而确定受试者在该试验中的收益或损失。20名PTSD患者和26名健康受试者的神经影像学数据经受住了质量控制程序，并被纳入。在体素和解剖学定义的感兴趣区域的分析，当收益对比损失，组间比较显示较小的双边纹状体激活的PTSD的主题。在创伤后应激障碍组中，与损失相比，纹状体对收益的激活较少，与自我报告的动机和社会缺陷有关。目前的数据支持这一假设，即创伤后应激障碍与异常处理的金钱结果，这种改变可能与某些方面的情感麻木。
Clinical impressions and preclinical work suggest that posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals. The protocol evaluated fMRI signal changes that anticipated or accompanied monetary gains and losses under varying conditions of controlled expectation. The “expectancy phase” entailed presentation of a promising, unpromising, or intermediate Wheel of Fortune-type spinner, whereas the “outcome phase” was defined by the arrow landing on one of three sectors of that spinner, thereby determining the subjects’ gain or loss for that trial. Neuroimaging data from 20 PTSD and 26 healthy subjects withstood quality control procedures and were included. In voxelwise and anatomically defined region of interest analyses, when gains were contrasted to losses, between-group comparison revealed smaller bilateral striatal activations in the PTSD subjects. In the PTSD group, less striatal activation to gains vs. losses was associated with more self-reported motivational and social deficits. The present data support the hypothesis that PTSD is associated with abnormal processing of monetary outcomes and that this alteration may be related to some aspects of emotional numbing.
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