Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells.
Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells.
复制标题
DOI：
10.3389/fgene.2011.00097
复制
发表时间：
2011
影响因子：
3.7
通讯作者：
Ochiya T
中科院分区：
文献类型：
--
作者：
Kosaka N;Ochiya T
microRNA（miRNAs）在发育、器官发生、代谢和体内平衡等生物学过程中起着重要的调节作用。miRNAs的失调导致疾病，特别是癌症。这通过多种机制发生，例如遗传改变、表观遗传调节或靶向miRNA的转录因子的表达改变。最近，发现细胞外miRNA在健康和患病患者的血液中循环。由于RNA酶在血流中丰富，因此大多数分泌性miRNA包含在凋亡小体、微泡和外来体中或与RNA结合蛋白结合。然而，分泌机制和生物学功能，以及胞外miRNAs的意义，在很大程度上仍不清楚。在这篇文章中，我们总结了最近同行评议的研究中最新和最重要的发现，分泌型miRNA参与生理和病理条件的许多方面，特别是癌症。此外，我们还讨论了癌症研究的一个新方面，即“分泌型miRNA”的出现。
microRNAs (miRNAs) have been identified as a fine-tuner in a wide array of biological processes, including development, organogenesis, metabolism, and homeostasis. Deregulation of miRNAs causes diseases, especially cancer. This occurs through a variety of mechanisms, such as genetic alterations, epigenetic regulation, or altered expression of transcription factors, which target miRNAs. Recently, it was discovered that extracellular miRNAs circulate in the blood of both healthy and diseased patients. Since RNase is abundant in the bloodstream, most of the secretory miRNAs are contained in apoptotic bodies, microvesicles, and exosomes or bound to the RNA-binding proteins. However, the secretory mechanism and biological function, as well as the significance of extracellular miRNAs, remain largely unclear. In this article, we summarize the latest and most significant discoveries in recent peer-reviewed research on secretory miRNA involvement in many aspects of physiological and pathological conditions, with a special focus on cancer. In addition, we discuss a new aspect of cancer research that is revealed by the emergence of “secretory miRNA.”
登录
查看更多内容
影响因子：
4.8
作者：
Gourzones C;Gelin A;Bombik I;Klibi J;Vérillaud B;Guigay J;Lang P;Témam S;Schneider V;Amiel C;Baconnais S;Jimenez AS;Busson P
通讯作者：
Busson P
影响因子：
11.2
作者：
Lim, Philip K.;Bliss, Sarah A.;Rameshwar, Pranela
通讯作者：
Rameshwar, Pranela
影响因子：
6.5
作者：
Lawrie, Charles H.;Gal, Shira;Harris, Adrian L.
通讯作者：
Harris, Adrian L.
影响因子：
56.9
作者：
Feinberg, EH;Hunter, CP
通讯作者：
Hunter, CP
细胞间纳米层介导的microRNA转移：肝癌细胞生长的环境调节机制。
影响因子：
13.5
作者：
Kogure, Takayuki;Lin, Wen-Lang;Yan, Irene K.;Braconi, Chiara;Patel, Tushar
通讯作者：
Patel, Tushar