New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism.
New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism.
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DOI：
10.3390/ijms23148011
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发表时间：
2022-07-20
影响因子：
5.6
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中科院分区：
文献类型：
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脑源性神经营养因子是一种被广泛研究的神经营养因子，涉及多种神经变性和精神疾病的病理学，包括但不限于帕金森病、阿尔茨海默病、亨廷顿病、创伤性脑损伤、严重抑郁症和精神分裂症。在这里，我们提供了一个关于BDNF和常见的人类单核苷酸多态性rs6265在驱动这些疾病的发病机制和康复方面的作用的简要总结，以及BDNF靶向治疗的现状。一个共同的趋势已经出现，将低BDNF水平（在中枢神经系统或外周检测到）与疾病状态相关联，这表明BDNF替代疗法可能具有临床前景。此外，我们介绍了一个独特的作用的BDNF前肽作为一种生物活性配体的证据，并需要继续研究其神经功能以外的分子伴侣。最后，我们强调了最新的研究，描述rs6265表达的神经退行性变的机制，以及矛盾的进展，在理解这种遗传变异的神经再生的作用。所有这些都是在个性化医疗的背景下讨论的，承认没有“一刀切”的神经退行性疾病或精神疾病的治疗，并继续研究多种BDNF亚型和遗传变异代表了一种发现成熟的治疗潜力的途径。
Brain-derived neurotrophic factor is an extensively studied neurotrophin implicated in the pathology of multiple neurodegenerative and psychiatric disorders including, but not limited to, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, traumatic brain injury, major de-pressive disorder, and schizophrenia. Here we provide a brief summary of current knowledge on the role of BDNF and the common human single nucleotide polymorphism, rs6265, in driving the pathogenesis and rehabilitation in these disorders, as well as the status of BDNF-targeted therapies. A common trend has emerged correlating low BDNF levels, either detected within the central nervous system or peripherally, to disease states, suggesting that BDNF replacement therapies may hold clinical promise. In addition, we introduce evidence for a distinct role of the BDNF pro-peptide as a biologically active ligand and the need for continuing studies on its neurological function outside of that as a molecular chaperone. Finally, we highlight the latest research describing the role of rs6265 expression in mechanisms of neurodegeneration as well as paradoxical advances in the understanding of this genetic variant in neuroregeneration. All of this is discussed in the context of personalized medicine, acknowledging there is no “one size fits all” therapy for neurodegenerative or psychiatric disorders and that continued study of the multiple BDNF isoforms and genetic variants represents an avenue for discovery ripe with therapeutic potential.
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影响因子：
--
作者：
Mai M;Akkad AD;Wieczorek S;Saft C;Andrich J;Kraus PH;Epplen JT;Arning L
通讯作者：
Arning L
影响因子：
4.7
作者：
Mei, Shufang;Chen, Wencai;Chen, Sijing;Hu, Yani;Dai, Xiaoyan;Liu, Xiujun
通讯作者：
Liu, Xiujun
影响因子：
5.3
作者：
Baydyuk M;Xu B
通讯作者：
Xu B
影响因子：
2.4
作者：
Adachi, N;Kohara, K;Tsumoto, T
通讯作者：
Tsumoto, T
影响因子：
2.5
作者：
Bialecka, Monika;Kurzawski, Mateusz;Slawek, Jarostaw
通讯作者：
Slawek, Jarostaw