Evaluation of the Relationship Between BDNF Val66Met Gene Polymorphism and Attention Deficit Hyperactivity Disorder: A Meta-Analysis.
Evaluation of the Relationship Between BDNF Val66Met Gene Polymorphism and Attention Deficit Hyperactivity Disorder: A Meta-Analysis.
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DOI：
10.3389/fpsyt.2022.888774
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发表时间：
2022
影响因子：
4.7
通讯作者：
Liu, Xiujun
中科院分区：
文献类型：
--
作者：
Mei, Shufang;Chen, Wencai;Chen, Sijing;Hu, Yani;Dai, Xiaoyan;Liu, Xiujun
注意缺陷多动障碍（ADHD）是儿童时期常见的神经行为障碍。脑源性神经营养因子（Brain-derived neurotrophic factor， BDNF）广泛分布于中枢神经系统，在神经发育中起重要作用。尽管之前的一些研究已经研究了BDNF中Val66Met多态性与多动症之间的关系，但结果却相互矛盾。本研究旨在通过荟萃分析评估病例对照和传播不平衡试验（TDT）研究中Val66Met多态性与ADHD之间的关系。使用关键词“rs6265”或“Val66Met”和“注意缺陷多动障碍”于2021年4月前在PubMed、Embase、Web of Science、万方和中国国家知识基础设施数据库中检索。提取基因型数据，计算优势比（ORs）和95%置信区间（ci）。15项研究，包括8692份样本（包括4364例病例，4328例对照）和1578个家庭，结果表明rs6265与ADHD易感性无关（OR = 0.95, 95% CI: 0.87-1.04, P = 0.291）。研究设计、种族和样本量的分层分析进一步支持rs6265与ADHD无关。本研究表明BDNF Val66Met基因多态性与ADHD易感性无关。
Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder in childhood. Brain-derived neurotrophic factor (BDNF) is widely distributed in the central nervous system and plays an important role in neural development. Despite several previous studies have examined the association between the Val66Met polymorphism BDNF and ADHD, the results are conflicting. This study aimed to evaluate the association between Val66Met polymorphism and ADHD in case-control and transmission disequilibrium test (TDT) studies using a meta-analysis. Keywords “rs6265” or “Val66Met” and “Attention deficit hyperactivity disorder” were used to search in the PubMed, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure databases before April 2021. Genotype data were extracted to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Fifteen studies, comprising of 8,692 samples (containing 4,364 cases, 4,328 controls) and 1,578 families were included and results demonstrated that rs6265 was not associated with susceptibility to ADHD (OR = 0.95, 95% CI: 0.87–1.04, P = 0.291). Stratified analyses by study design, ethnicity, and sample size further supported that rs6265 was not associated with ADHD. The present study shows that the polymorphism of the BDNF Val66Met gene is not associated with susceptibility to ADHD.
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影响因子：
1.9
作者：
Jeong HI;Ji ES;Kim SH;Kim TW;Baek SB;Choi SW
通讯作者：
Choi SW
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影响因子：
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作者：
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通讯作者：
Larsson H
影响因子：
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作者：
Heal, David J;Smith, Sharon L;Findling, Robert L
通讯作者：
Findling, Robert L
影响因子：
4.7
作者：
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通讯作者：
Angelatou, Fevronia
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N