Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease.
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease.
复制标题
DOI：
10.1016/j.neurobiolaging.2012.10.018
复制
发表时间：
2013-04
影响因子：
4.2
通讯作者：
Teipel S
中科院分区：
文献类型：
--
作者：
Grothe M;Heinsen H;Teipel S
来自横断面体内成像研究的最新证据表明，即使在痴呆前期，阿尔茨海默病（AD）中胆碱能基底前脑（BF）的萎缩也可以与正常的年龄相关退化区分开来。需要纵向研究设计来明确从正常衰老到 AD 过渡过程中 BF 变性的动态。我们将最近开发的 BF 体内体积测定技术应用于 82 名最初健康的老年人（HE，60-93 岁）和 50 名非常轻度 AD 患者（vmAD，CDR=0.5）的连续 MRI 扫描，并进行了平均 3±1.5 年的临床随访。研究发现，即使在认知稳定的 HE 中，BF 萎缩率也显着高于全脑萎缩率。与健康对照相比，vmAD 显示基线 BF 体积减少，并且随着时间的推移体积损失增加。与保持稳定的患者相比，进展患者的 BF 萎缩更为明显。胆碱能 BF 在衰老过程中经历不成比例的退化，AD 的存在进一步加剧了这种退化。
Recent evidence from cross-sectional in-vivo imaging studies suggests that atrophy of the cholinergic basal forebrain (BF) in Alzheimer’s disease (AD) can be distinguished from normal age-related degeneration even at pre-dementia stages of the disease. Longitudinal study designs are needed to specify the dynamics of BF degeneration in the transition from normal aging to AD. We applied recently developed techniques for in-vivo volumetry of the BF to serial MRI scans of 82 initially healthy elderly individuals (HE, 60–93 years) and 50 patients with very mild AD (vmAD, CDR=0.5) that were clinically followed over an average of 3±1.5 years. BF atrophy rates were found to be significantly higher than rates of global brain shrinkage even in cognitively stable HE. Compared to healthy controls, vmAD showed reduced BF volumes at baseline and increased volume loss over time. Atrophy of the BF was more pronounced in progressive patients compared to those that remained stable. The cholinergic BF undergoes disproportionate degeneration in the aging process, which is further increased by the presence of AD.
登录
查看更多内容
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
4.2
作者：
George S;Mufson EJ;Leurgans S;Shah RC;Ferrari C;deToledo-Morrell L
通讯作者：
deToledo-Morrell L
影响因子：
3.7
作者：
Ewers, Michael;Insel, Philip;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
DOI：
10.1007/s00259-010-1644-5
发表时间：
2011-03-01
影响因子：
9.1
作者：
Kendziorra, Kai;Wolf, Henrike;Sabri, Osama
通讯作者：
Sabri, Osama
影响因子：
3.2
作者：
Marcus DS;Fotenos AF;Csernansky JG;Morris JC;Buckner RL
通讯作者：
Buckner RL